Going Beyond Antibiotics: Natural Plant Extracts as an Emergent Strategy to Combat Biofilm-Associated Infections.

Kou, J; Xin, TY; McCarron, P; Gupta, G; Dureja, H; Satija, S; Mehta, M; Bakshi, HA; Tambuwala, MM; Collet, T; Dua, K; Chellappan, DK

Going Beyond Antibiotics: Natural Plant Extracts as an Emergent Strategy to Combat Biofilm-Associated Infections.

Kou, J Xin, TY McCarron, P Gupta, G Dureja, H Satija, S

Mehta, M Bakshi, HA Tambuwala, MM Collet, T Dua, K

Chellappan, DK

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Publisher:: Begell House
Publication Type:: Journal Article
Citation:: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2020, 39, (2), pp. 125-136
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Kou, J
dc.contributor.author	Xin, TY
dc.contributor.author	McCarron, P
dc.contributor.author	Gupta, G
dc.contributor.author	Dureja, H
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Mehta, M
dc.contributor.author	Bakshi, HA
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Collet, T
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Chellappan, DK
dc.date.accessioned	2021-05-14T02:59:29Z
dc.date.available	2021-05-14T02:59:29Z
dc.date.issued	2020-01
dc.identifier.citation	Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2020, 39, (2), pp. 125-136
dc.identifier.issn	0731-8898
dc.identifier.issn	2162-6537
dc.identifier.uri	http://hdl.handle.net/10453/148899
dc.description.abstract	Biofilms are a collective of multiple types of bacteria that develop on a variety of surfaces. Biofilm development results in heightened resistance to antibiotics. Quorum sensing plays an important role in biofilm development as it is one of the common communication mechanisms within cells, which balances and stabilizes the environment, when the amount of bacteria increases. Because of the important implications of the roles biofilms play in infectious diseases, it is crucial to investigate natural antibacterial agents that are able to regulate biofilm formation and development. Various studies have suggested that natural plant products have the potential to suppress bacterial growth and exhibit chemopreventive traits in the modulation of biofilm development. In this review, we discuss and collate potential antibiofilm drugs and biological molecules from natural sources, along with their underlying mechanisms of action. In addition, we also discuss the antibiofilm drugs that are currently under clinical trials and highlight their potential future uses.
dc.format	Print
dc.language	eng
dc.publisher	Begell House
dc.relation.ispartof	Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
dc.relation.isbasedon	10.1615/jenvironpatholtoxicoloncol.2020032665
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.mesh	Humans
dc.subject.mesh	Biofilms
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Drug Resistance, Bacterial
dc.subject.mesh	Quorum Sensing
dc.subject.mesh	Host-Pathogen Interactions
dc.subject.mesh	Infections
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Biofilms
dc.subject.mesh	Drug Resistance, Bacterial
dc.subject.mesh	Host-Pathogen Interactions
dc.subject.mesh	Humans
dc.subject.mesh	Infections
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Quorum Sensing
dc.title	Going Beyond Antibiotics: Natural Plant Extracts as an Emergent Strategy to Combat Biofilm-Associated Infections.
dc.type	Journal Article
utslib.citation.volume	39
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2021-05-14T02:59:28Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	39
utslib.citation.issue	2

Abstract:

Biofilms are a collective of multiple types of bacteria that develop on a variety of surfaces. Biofilm development results in heightened resistance to antibiotics. Quorum sensing plays an important role in biofilm development as it is one of the common communication mechanisms within cells, which balances and stabilizes the environment, when the amount of bacteria increases. Because of the important implications of the roles biofilms play in infectious diseases, it is crucial to investigate natural antibacterial agents that are able to regulate biofilm formation and development. Various studies have suggested that natural plant products have the potential to suppress bacterial growth and exhibit chemopreventive traits in the modulation of biofilm development. In this review, we discuss and collate potential antibiofilm drugs and biological molecules from natural sources, along with their underlying mechanisms of action. In addition, we also discuss the antibiofilm drugs that are currently under clinical trials and highlight their potential future uses.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/148899