Time to sputum culture conversion and its associated factors among multidrug-resistant tuberculosis patients in Eastern Africa: A systematic review and meta-analysis.
- Publisher:
- Elsevier BV
- Publication Type:
- Journal Article
- Citation:
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2020, 98, pp. 230-236
- Issue Date:
- 2020-09
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Assemie, MA | |
dc.contributor.author | Alene, M | |
dc.contributor.author | Petrucka, P | |
dc.contributor.author | Leshargie, CT | |
dc.contributor.author | Ketema, DB | |
dc.date.accessioned | 2021-06-02T06:44:42Z | |
dc.date.available | 2020-06-06 | |
dc.date.available | 2021-06-02T06:44:42Z | |
dc.date.issued | 2020-09 | |
dc.identifier.citation | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2020, 98, pp. 230-236 | |
dc.identifier.issn | 1201-9712 | |
dc.identifier.issn | 1878-3511 | |
dc.identifier.uri | http://hdl.handle.net/10453/149369 | |
dc.description.abstract | <h4>Objective</h4>This study aimed to consider the estimated time to multi-resistant tuberculosis culture conversion, and associated factors, in order to enhance evidence utilization in eastern Africa.<h4>Methods</h4>We systematically identified available articles on multidrug-resistant tuberculosis culture conversion using PubMed, Scopus, Cochrane Library, Web of Science core collection, and Science Direct databases. A random-effects model was employed using the R 3.6.1 version and Stata/se 14 software.<h4>Results</h4>Nine articles with a sample size of 2458 multidrug-resistant tuberculosis patients were included. The two-month culture conversion rate was 75.4%, with a median time of 61.2 days (interquartile range: 48.6-73.8). In the included studies, favorable treatment outcomes of MDR-TB patients were seen in 75% of the cases, while unfavorable treatment outcomes were seen in 18% (10% deaths, 7% defaulted, and 1% treatment failure) of the cases. The independent factor for delayed sputum culture conversion was body mass index below 18.5kg/m<sup>2</sup> (HR=3.1, 95% CI: 2.0, 6.7).<h4>Conclusion</h4>The median time to sputum culture conversion was 61.2 days, which is a reasonably short time. Body mass index was the identified associated factor leading to delayed culture conversion. Therefore, there is a need for awareness of how to improve the nutritional status of multidrug-resistant tuberculosis patients through appropriate nutritional supports. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases | |
dc.relation.isbasedon | 10.1016/j.ijid.2020.06.029 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0605 Microbiology, 1108 Medical Microbiology, 1117 Public Health and Health Services | |
dc.subject.classification | Microbiology | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Africa, Eastern | |
dc.subject.mesh | Antitubercular Agents | |
dc.subject.mesh | Data Management | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Mycobacterium tuberculosis | |
dc.subject.mesh | Sputum | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Tuberculosis, Multidrug-Resistant | |
dc.subject.mesh | Young Adult | |
dc.subject.mesh | Sputum | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mycobacterium tuberculosis | |
dc.subject.mesh | Tuberculosis, Multidrug-Resistant | |
dc.subject.mesh | Antitubercular Agents | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Africa, Eastern | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Young Adult | |
dc.subject.mesh | Data Management | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Africa, Eastern | |
dc.subject.mesh | Antitubercular Agents | |
dc.subject.mesh | Data Management | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Mycobacterium tuberculosis | |
dc.subject.mesh | Sputum | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Tuberculosis, Multidrug-Resistant | |
dc.subject.mesh | Young Adult | |
dc.title | Time to sputum culture conversion and its associated factors among multidrug-resistant tuberculosis patients in Eastern Africa: A systematic review and meta-analysis. | |
dc.type | Journal Article | |
utslib.citation.volume | 98 | |
utslib.location.activity | Canada | |
utslib.for | 0605 Microbiology | |
utslib.for | 1108 Medical Microbiology | |
utslib.for | 1117 Public Health and Health Services | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health/Public Health | |
utslib.copyright.status | open_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2021-06-02T06:44:41Z | |
pubs.publication-status | Published | |
pubs.volume | 98 |
Abstract:
Objective
This study aimed to consider the estimated time to multi-resistant tuberculosis culture conversion, and associated factors, in order to enhance evidence utilization in eastern Africa.Methods
We systematically identified available articles on multidrug-resistant tuberculosis culture conversion using PubMed, Scopus, Cochrane Library, Web of Science core collection, and Science Direct databases. A random-effects model was employed using the R 3.6.1 version and Stata/se 14 software.Results
Nine articles with a sample size of 2458 multidrug-resistant tuberculosis patients were included. The two-month culture conversion rate was 75.4%, with a median time of 61.2 days (interquartile range: 48.6-73.8). In the included studies, favorable treatment outcomes of MDR-TB patients were seen in 75% of the cases, while unfavorable treatment outcomes were seen in 18% (10% deaths, 7% defaulted, and 1% treatment failure) of the cases. The independent factor for delayed sputum culture conversion was body mass index below 18.5kg/m2 (HR=3.1, 95% CI: 2.0, 6.7).Conclusion
The median time to sputum culture conversion was 61.2 days, which is a reasonably short time. Body mass index was the identified associated factor leading to delayed culture conversion. Therefore, there is a need for awareness of how to improve the nutritional status of multidrug-resistant tuberculosis patients through appropriate nutritional supports.Please use this identifier to cite or link to this item:
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