Asymmetry in the assembly of the RNAi enzyme complex

Cell Press
Publication Type:
Journal Article
Cell, 2003, 115 (2), pp. 199 - 208
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A key step in RNA interference (RNAi) is assembly of the RISC, the protein-siRNA complex that mediates target RNA cleavage. Here, we show that the two strands of an siRNA duplex are not equally eligible for assembly into RISC. Rather, both the absolute a
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