Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
- Publisher:
- Cell Press
- Publication Type:
- Journal Article
- Citation:
- Molecular Cell, 2002, 10 (3), pp. 537 - 548
- Issue Date:
- 2002-01
Closed Access
Full metadata record
| Field | Value | Language |
|---|---|---|
| dc.contributor.author | Schwarz, D | en_US |
| dc.contributor.author | Hutvagner, GJ | en_US |
| dc.contributor.author | Haley, B | en_US |
| dc.contributor.author | Zamore, P | en_US |
| dc.date.issued | 2002-01 | en_US |
| dc.identifier.citation | Molecular Cell, 2002, 10 (3), pp. 537 - 548 | en_US |
| dc.identifier.issn | 1097-2765 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10453/14988 | |
| dc.description.abstract | In Drosophila, two features of small interfering RNA (siRNA) structure-5' phosphates and 3' hydroxyls are reported to be essential for RNA interference (RNAi). Here, we show that as in Drosophila, a 5' phosphate is required for siRNA function in human He | en_US |
| dc.format | Esha Dutt | en_US |
| dc.publisher | Cell Press | en_US |
| dc.relation.ispartof | Molecular Cell | en_US |
| dc.relation.isbasedon | 10.1016/S1097-2765(02)00651-2 | en_US |
| dc.subject.classification | Developmental Biology | en_US |
| dc.subject.mesh | Hela Cells | en_US |
| dc.subject.mesh | Animals | en_US |
| dc.subject.mesh | Humans | en_US |
| dc.subject.mesh | Drosophila melanogaster | en_US |
| dc.subject.mesh | Phosphates | en_US |
| dc.subject.mesh | Endoribonucleases | en_US |
| dc.subject.mesh | Ribonuclease III | en_US |
| dc.subject.mesh | RNA, Small Interfering | en_US |
| dc.subject.mesh | RNA, Double-Stranded | en_US |
| dc.subject.mesh | Gene Expression Regulation | en_US |
| dc.subject.mesh | RNA Interference | en_US |
| dc.subject.mesh | Genes, Insect | en_US |
| dc.subject.mesh | Animals | en_US |
| dc.subject.mesh | Drosophila melanogaster | en_US |
| dc.subject.mesh | Endoribonucleases | en_US |
| dc.subject.mesh | Gene Expression Regulation | en_US |
| dc.subject.mesh | Genes, Insect | en_US |
| dc.subject.mesh | HeLa Cells | en_US |
| dc.subject.mesh | Humans | en_US |
| dc.subject.mesh | Phosphates | en_US |
| dc.subject.mesh | RNA Interference | en_US |
| dc.subject.mesh | RNA, Double-Stranded | en_US |
| dc.subject.mesh | RNA, Small Interfering | en_US |
| dc.subject.mesh | Ribonuclease III | en_US |
| dc.title | Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways | en_US |
| dc.type | Journal Article | |
| utslib.citation.volume | 3 | en_US |
| utslib.citation.volume | 10 | en_US |
| utslib.location.activity | ISI:000178330900012 | en_US |
| utslib.for | 0601 Biochemistry and Cell Biology | en_US |
| utslib.for | 06 Biological Sciences | en_US |
| utslib.for | 11 Medical And Health Sciences | en_US |
| dc.location.activity | ISI:000178330900012 | en_US |
| pubs.embargo.period | Not known | en_US |
| pubs.organisational-group | /University of Technology Sydney | |
| pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
| pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
| utslib.copyright.status | closed_access | |
| pubs.consider-herdc | false | en_US |
| pubs.issue | 3 | en_US |
| pubs.notes | OK | en_US |
| pubs.volume | 10 | en_US |
Files in This Item:
| Filename | Description | Size | |||
|---|---|---|---|---|---|
 | 2010003461OK.pdf | 623.54 kB | Adobe PDF |
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Abstract:
In Drosophila, two features of small interfering RNA (siRNA) structure-5' phosphates and 3' hydroxyls are reported to be essential for RNA interference (RNAi). Here, we show that as in Drosophila, a 5' phosphate is required for siRNA function in human He
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