Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways

Cell Press
Publication Type:
Journal Article
Molecular Cell, 2002, 10 (3), pp. 537 - 548
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In Drosophila, two features of small interfering RNA (siRNA) structure-5' phosphates and 3' hydroxyls are reported to be essential for RNA interference (RNAi). Here, we show that as in Drosophila, a 5' phosphate is required for siRNA function in human He
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