Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Sharma, A; Hawthorne, S; Jha, SK; Jha, NK; Kumar, D; Girgis, S; Goswami, VK; Gupta, G; Singh, S; Dureja, H; Chellappan, DK; Dua, K

Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Sharma, A Hawthorne, S Jha, SK Jha, NK Kumar, D Girgis, S Goswami, VK Gupta, G Singh, S Dureja, H Chellappan, DK Dua, K

Permalink

Publisher:: Future Medicine Ltd
Publication Type:: Journal Article
Citation:: Nanomedicine

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Accepted versionAdobe PDF (2.99 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Sharma, A
dc.contributor.author	Hawthorne, S
dc.contributor.author	Jha, SK
dc.contributor.author	Jha, NK
dc.contributor.author	Kumar, D
dc.contributor.author	Girgis, S
dc.contributor.author	Goswami, VK
dc.contributor.author	Gupta, G
dc.contributor.author	Singh, S
dc.contributor.author	Dureja, H
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2021-07-24T08:48:29Z
dc.date.available	2021-07-24T08:48:29Z
dc.identifier.citation	Nanomedicine
dc.identifier.issn	1743-5889
dc.identifier.issn	1748-6963
dc.identifier.uri	http://hdl.handle.net/10453/149928
dc.description.abstract	<jats:p> Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area. </jats:p>
dc.language	en
dc.publisher	Future Medicine Ltd
dc.relation.ispartof	Nanomedicine
dc.relation.isbasedon	10.2217/nnm-2021-0066
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0306 Physical Chemistry (incl. Structural), 1004 Medical Biotechnology, 1007 Nanotechnology
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells
dc.type	Journal Article
utslib.for	0306 Physical Chemistry (incl. Structural)
utslib.for	1004 Medical Biotechnology
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2021-07-24T08:48:26Z
pubs.publication-status	Published online

Abstract:

Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/149928