A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS).

Rose, L; Burry, L; Agar, M; Campbell, NL; Clarke, M; Lee, J; Marshall, JC; Devlin, JW; Blackwood, B; Needham, DM; Siddiqi, N; Page, V; Del-COrS Group,

A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS).

Rose, L Burry, L Agar, M

Campbell, NL Clarke, M Lee, J Marshall, JC Devlin, JW Blackwood, B Needham, DM Siddiqi, N Page, V Del-COrS Group,

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Publisher:: Ovid Technologies (Wolters Kluwer Health)
Publication Type:: Journal Article
Citation:: Critical care medicine, 2021, 49, (9), pp. 1535-1546
Issue Date:: 2021-09

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Field	Value	Language
dc.contributor.author	Rose, L
dc.contributor.author	Burry, L
dc.contributor.author	Agar, M https://orcid.org/0000-0002-6756-6119
dc.contributor.author	Campbell, NL
dc.contributor.author	Clarke, M
dc.contributor.author	Lee, J
dc.contributor.author	Marshall, JC
dc.contributor.author	Devlin, JW
dc.contributor.author	Blackwood, B
dc.contributor.author	Needham, DM
dc.contributor.author	Siddiqi, N
dc.contributor.author	Page, V
dc.contributor.author	Del-COrS Group,
dc.date.accessioned	2021-09-03T04:45:02Z
dc.date.available	2021-09-03T04:45:02Z
dc.date.issued	2021-09
dc.identifier.citation	Critical care medicine, 2021, 49, (9), pp. 1535-1546
dc.identifier.issn	0090-3493
dc.identifier.issn	1530-0293
dc.identifier.uri	http://hdl.handle.net/10453/150311
dc.description.abstract	Objectives: Delirium in critically ill adults is highly prevalent and has multiple negative consequences. To-date, trials of interventions to prevent or treat delirium report heterogenous outcomes. To develop international consensus among key stakeholders for a core outcome set for future trials of interventions to prevent and/or treat delirium in critically ill adults. Design: Core outcome set development, as recommended by the Core Outcome Measures in Effectiveness Trials Handbook. Methods of generating items for the core outcome set included a systematic review and qualitative interviews with ICU survivors and family members. Consensus methods include a two-round web-based Delphi process and a face-to-face meeting using nominal group technique methods. Subjects: International representatives from three stakeholder groups: 1) clinical researchers, 2) ICU interprofessional clinicians, and 3) ICU survivors and family members. Setting: Telephone interviews, web-based surveys, and a face-to-face consensus meeting held at the 2019 European Delirium Intervention: None. Measurements and main results: Qualitative interviews with 24 ICU survivors and family members identified 36 potential outcomes; six were additional to the 97 identified from the systematic review. After item reduction, 32 outcomes were presented in Delphi Round 1; 179 experts participated, 38 ICU survivors/family members (21%), 100 clinicians (56%), 41 researchers (23%). Three additional outcomes were added to Round 2; 134 Round 1 participants (75%) completed it. Upon conclusion of the consensus building processes, the final core outcome set comprised seven outcomes: delirium occurrence (including prevalence or incidence); delirium severity; time to delirium resolution; health-related quality of life; emotional distress (i.e., anxiety, depression, acute and posttraumatic stress); cognition (including memory); and mortality. Conclusions: This core outcome set, endorsed by the American and Australian Delirium Societies and European Delirium Association, is recommended for future clinical trials evaluating delirium prevention or treatment interventions in critically ill adults.
dc.format	Print
dc.language	eng
dc.publisher	Ovid Technologies (Wolters Kluwer Health)
dc.relation.ispartof	Critical care medicine
dc.relation.isbasedon	10.1097/ccm.0000000000005028
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1110 Nursing, 1117 Public Health and Health Services
dc.subject.classification	Emergency & Critical Care Medicine
dc.title	A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS).
dc.type	Journal Article
utslib.citation.volume	49
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1110 Nursing
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-09-03T04:45:01Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	49
utslib.citation.issue	9

Abstract:

Objectives: Delirium in critically ill adults is highly prevalent and has multiple negative consequences. To-date, trials of interventions to prevent or treat delirium report heterogenous outcomes. To develop international consensus among key stakeholders for a core outcome set for future trials of interventions to prevent and/or treat delirium in critically ill adults. Design: Core outcome set development, as recommended by the Core Outcome Measures in Effectiveness Trials Handbook. Methods of generating items for the core outcome set included a systematic review and qualitative interviews with ICU survivors and family members. Consensus methods include a two-round web-based Delphi process and a face-to-face meeting using nominal group technique methods. Subjects: International representatives from three stakeholder groups: 1) clinical researchers, 2) ICU interprofessional clinicians, and 3) ICU survivors and family members. Setting: Telephone interviews, web-based surveys, and a face-to-face consensus meeting held at the 2019 European Delirium Intervention: None. Measurements and main results: Qualitative interviews with 24 ICU survivors and family members identified 36 potential outcomes; six were additional to the 97 identified from the systematic review. After item reduction, 32 outcomes were presented in Delphi Round 1; 179 experts participated, 38 ICU survivors/family members (21%), 100 clinicians (56%), 41 researchers (23%). Three additional outcomes were added to Round 2; 134 Round 1 participants (75%) completed it. Upon conclusion of the consensus building processes, the final core outcome set comprised seven outcomes: delirium occurrence (including prevalence or incidence); delirium severity; time to delirium resolution; health-related quality of life; emotional distress (i.e., anxiety, depression, acute and posttraumatic stress); cognition (including memory); and mortality. Conclusions: This core outcome set, endorsed by the American and Australian Delirium Societies and European Delirium Association, is recommended for future clinical trials evaluating delirium prevention or treatment interventions in critically ill adults.

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http://hdl.handle.net/10453/150311