A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study

Rose, L; Burry, L; Agar, M; Blackwood, B; Campbell, NL; Clarke, M; Devlin, JW; Lee, J; Marshall, JC; Needham, DM; Siddiqi, N; Page, V

A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study

Rose, L Burry, L Agar, M

Blackwood, B Campbell, NL Clarke, M Devlin, JW Lee, J Marshall, JC Needham, DM Siddiqi, N Page, V

Permalink

Publisher:: BMC
Publication Type:: Journal Article
Citation:: BMC Medicine, 2021, 19, (1)
Issue Date:: 2021-06-18

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (1.21 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Rose, L
dc.contributor.author	Burry, L
dc.contributor.author	Agar, M https://orcid.org/0000-0002-6756-6119
dc.contributor.author	Blackwood, B
dc.contributor.author	Campbell, NL
dc.contributor.author	Clarke, M
dc.contributor.author	Devlin, JW
dc.contributor.author	Lee, J
dc.contributor.author	Marshall, JC
dc.contributor.author	Needham, DM
dc.contributor.author	Siddiqi, N
dc.contributor.author	Page, V
dc.date.accessioned	2021-09-03T04:52:05Z
dc.date.available	2021-05-21
dc.date.available	2021-09-03T04:52:05Z
dc.date.issued	2021-06-18
dc.identifier.citation	BMC Medicine, 2021, 19, (1)
dc.identifier.issn	1741-7015
dc.identifier.issn	1741-7015
dc.identifier.uri	http://hdl.handle.net/10453/150312
dc.description.abstract	<h4>Background</h4>Trials of interventions to prevent or treat delirium in adults in an acute hospital setting report heterogeneous outcomes. Our objective was to develop international consensus among key stakeholders for a core outcome set (COS) for future trials of interventions to prevent and/or treat delirium in adults with an acute care hospital admission and not admitted to an intensive care unit.<h4>Methods</h4>A rigorous COS development process was used including a systematic review, qualitative interviews, modified Delphi consensus process, and in-person consensus using nominal group technique (registration http://www.comet - initiative.org/studies/details/796 ). Participants in qualitative interviews were delirium survivors or family members. Participants in consensus methods comprised international representatives from three stakeholder groups: researchers, clinicians, and delirium survivors and family members.<h4>Results</h4>Item generation identified 8 delirium-specific outcomes and 71 other outcomes from 183 studies, and 30 outcomes from 18 qualitative interviews, including 2 that were not extracted from the systematic review. De-duplication of outcomes and formal consensus processes involving 110 experts including researchers (N = 32), clinicians (N = 63), and delirium survivors and family members (N = 15) resulted in a COS comprising 6 outcomes: delirium occurrence and reoccurrence, delirium severity, delirium duration, cognition, emotional distress, and health-related quality of life. Study limitations included exclusion of non-English studies and stakeholders and small representation of delirium survivors/family at the in-person consensus meeting.<h4>Conclusions</h4>This COS, endorsed by the American and Australian Delirium Societies and European Delirium Association, is recommended for future clinical trials evaluating delirium prevention or treatment interventions in adults presenting to an acute care hospital and not admitted to an intensive care unit.
dc.format	Electronic
dc.language	eng
dc.publisher	BMC
dc.relation.ispartof	BMC Medicine
dc.relation.isbasedon	10.1186/s12916-021-02015-3
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	General & Internal Medicine
dc.title	A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study
dc.type	Journal Article
utslib.citation.volume	19
utslib.location.activity	England
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2021-09-03T04:52:01Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	19
utslib.citation.issue	1

Abstract:

Background

Trials of interventions to prevent or treat delirium in adults in an acute hospital setting report heterogeneous outcomes. Our objective was to develop international consensus among key stakeholders for a core outcome set (COS) for future trials of interventions to prevent and/or treat delirium in adults with an acute care hospital admission and not admitted to an intensive care unit.

Methods

A rigorous COS development process was used including a systematic review, qualitative interviews, modified Delphi consensus process, and in-person consensus using nominal group technique (registration http://www.comet - initiative.org/studies/details/796 ). Participants in qualitative interviews were delirium survivors or family members. Participants in consensus methods comprised international representatives from three stakeholder groups: researchers, clinicians, and delirium survivors and family members.

Results

Item generation identified 8 delirium-specific outcomes and 71 other outcomes from 183 studies, and 30 outcomes from 18 qualitative interviews, including 2 that were not extracted from the systematic review. De-duplication of outcomes and formal consensus processes involving 110 experts including researchers (N = 32), clinicians (N = 63), and delirium survivors and family members (N = 15) resulted in a COS comprising 6 outcomes: delirium occurrence and reoccurrence, delirium severity, delirium duration, cognition, emotional distress, and health-related quality of life. Study limitations included exclusion of non-English studies and stakeholders and small representation of delirium survivors/family at the in-person consensus meeting.

Conclusions

This COS, endorsed by the American and Australian Delirium Societies and European Delirium Association, is recommended for future clinical trials evaluating delirium prevention or treatment interventions in adults presenting to an acute care hospital and not admitted to an intensive care unit.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/150312