Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials.

Zheng, J; Wang, B; Xiang, J; Yu, Z

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials.

Zheng, J Wang, B Xiang, J Yu, Z

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Publisher:: Hindawi Limited
Publication Type:: Journal Article
Citation:: Bioinorganic chemistry and applications, 2021, 2021, pp. 7625585
Issue Date:: 2021-01

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Field	Value	Language
dc.contributor.author	Zheng, J
dc.contributor.author	Wang, B
dc.contributor.author	Xiang, J
dc.contributor.author	Yu, Z https://orcid.org/0000-0002-8888-4570
dc.date.accessioned	2021-09-07T09:54:38Z
dc.date.available	2021-06-07
dc.date.available	2021-09-07T09:54:38Z
dc.date.issued	2021-01
dc.identifier.citation	Bioinorganic chemistry and applications, 2021, 2021, pp. 7625585
dc.identifier.issn	1565-3633
dc.identifier.issn	1687-479X
dc.identifier.uri	http://hdl.handle.net/10453/150389
dc.description.abstract	In order to achieve the controlled release of curcumin, HPMC (hydroxypropyl methyl cellulose) was spray dried with curcumin and lactose. The spray-dried materials were pressed into tablets with a diameter of 8 mm, and their release characteristics <i>in vitro</i> were measured. <i>In vitro</i> experiments showed that the release of curcumin from the HPMC mixture was significantly slower due to the sustained-release property of HPMC as a typical excipient. The release profile of curcumin from the HPMC mixture was relatively stable for a controlled release. SEM images show that the HPMC co-spray-dried powders have crumpled surfaces due to the large molecular weight of HPMC. DSC, XRD, FTIR, N<sub>2</sub> adsorption, and TGA have been measured for the spray-dried curcumin materials. This work indicates that HPMC can be used as a controlled-release excipient for curcumin preparations.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Hindawi Limited
dc.relation.ispartof	Bioinorganic chemistry and applications
dc.relation.isbasedon	10.1155/2021/7625585
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0302 Inorganic Chemistry, 0399 Other Chemical Sciences
dc.subject.classification	Inorganic & Nuclear Chemistry
dc.title	Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials.
dc.type	Journal Article
utslib.citation.volume	2021
utslib.location.activity	Egypt
utslib.for	0302 Inorganic Chemistry
utslib.for	0399 Other Chemical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/DVC (Corporate Services)
utslib.copyright.status	open_access	*
dc.date.updated	2021-09-07T09:54:35Z
pubs.publication-status	Published
pubs.volume	2021

Abstract:

In order to achieve the controlled release of curcumin, HPMC (hydroxypropyl methyl cellulose) was spray dried with curcumin and lactose. The spray-dried materials were pressed into tablets with a diameter of 8 mm, and their release characteristics in vitro were measured. In vitro experiments showed that the release of curcumin from the HPMC mixture was significantly slower due to the sustained-release property of HPMC as a typical excipient. The release profile of curcumin from the HPMC mixture was relatively stable for a controlled release. SEM images show that the HPMC co-spray-dried powders have crumpled surfaces due to the large molecular weight of HPMC. DSC, XRD, FTIR, N₂ adsorption, and TGA have been measured for the spray-dried curcumin materials. This work indicates that HPMC can be used as a controlled-release excipient for curcumin preparations.

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http://hdl.handle.net/10453/150389