Asthma and risk of infection, hospitalization, ICU admission and mortality from COVID-19: Systematic review and meta-analysis.

Sunjaya, AP; Allida, SM; Di Tanna, GL; Jenkins, C

Asthma and risk of infection, hospitalization, ICU admission and mortality from COVID-19: Systematic review and meta-analysis.

Sunjaya, AP Allida, SM Di Tanna, GL Jenkins, C

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Publisher:: Informa UK Limited
Publication Type:: Journal Article
Citation:: The Journal of asthma : official journal of the Association for the Care of Asthma, 2021, pp. 1-14
Issue Date:: 2021-04

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Field	Value	Language
dc.contributor.author	Sunjaya, AP
dc.contributor.author	Allida, SM
dc.contributor.author	Di Tanna, GL
dc.contributor.author	Jenkins, C
dc.date.accessioned	2021-09-09T04:54:00Z
dc.date.available	2021-09-09T04:54:00Z
dc.date.issued	2021-04
dc.identifier.citation	The Journal of asthma : official journal of the Association for the Care of Asthma, 2021, pp. 1-14
dc.identifier.issn	0277-0903
dc.identifier.issn	1532-4303
dc.identifier.uri	http://hdl.handle.net/10453/150429
dc.description.abstract	<h4>Objective</h4>As COVID-19 spreads across the world, there are concerns that people with asthma are at a higher risk of acquiring the disease, or of poorer outcomes. This systematic review aimed to summarize evidence on the risk of infection, severe illness and death from COVID-19 in people with asthma.<h4>Data sources and study selection</h4>A comprehensive search of electronic databases including preprint repositories and WHO COVID-19 database was conducted (until 26 May 2020). Studies reporting COVID-19 in people with asthma were included. For binary outcomes, we performed Sidik-Jonkman random effects meta-analysis. We explored quantitative heterogeneity by subgroup analyses, meta regression and evaluating the I<sup>2</sup> statistic.<h4>Results</h4>Fifty-seven studies with an overall sample size of 587 280 were included. The prevalence of asthma among those infected with COVID-19 was 7.46% (95% CI = 6.25-8.67). Non-severe asthma was more common than severe asthma (9.61% vs. 4.13%). Pooled analysis showed a 14% risk ratio reduction in acquiring COVID-19 (95% CI = 0.80-0.94; <i>p</i> < 0.0001) and 13% reduction in hospitalization with COVID-19 (95% CI = 0.77-0.99, <i>p</i> = 0.03) for people with asthma compared with those without. There was no significant difference in the combined risk of requiring admission to ICU and/or receiving mechanical ventilation for people with asthma (RR = 0.87 95% CI = 0.94-1.37; <i>p</i> = 0.19) and risk of death from COVID-19 (RR = 0.87; 95% CI = 0.68-1.10; <i>p</i> = 0.25).<h4>Conclusion</h4>The findings from this study suggest that the prevalence of people with asthma among COVID-19 patients is similar to the global prevalence of asthma. The overall findings suggest that people with asthma have a lower risk than those without asthma for acquiring COVID-19 and have similar clinical outcomes.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Informa UK Limited
dc.relation.ispartof	The Journal of asthma : official journal of the Association for the Care of Asthma
dc.relation.isbasedon	10.1080/02770903.2021.1888116
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1117 Public Health and Health Services
dc.subject.classification	Allergy
dc.title	Asthma and risk of infection, hospitalization, ICU admission and mortality from COVID-19: Systematic review and meta-analysis.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
dc.date.updated	2021-09-09T04:53:54Z
pubs.publication-status	Published

Abstract:

Objective

As COVID-19 spreads across the world, there are concerns that people with asthma are at a higher risk of acquiring the disease, or of poorer outcomes. This systematic review aimed to summarize evidence on the risk of infection, severe illness and death from COVID-19 in people with asthma.

Data sources and study selection

A comprehensive search of electronic databases including preprint repositories and WHO COVID-19 database was conducted (until 26 May 2020). Studies reporting COVID-19 in people with asthma were included. For binary outcomes, we performed Sidik-Jonkman random effects meta-analysis. We explored quantitative heterogeneity by subgroup analyses, meta regression and evaluating the I² statistic.

Results

Fifty-seven studies with an overall sample size of 587 280 were included. The prevalence of asthma among those infected with COVID-19 was 7.46% (95% CI = 6.25-8.67). Non-severe asthma was more common than severe asthma (9.61% vs. 4.13%). Pooled analysis showed a 14% risk ratio reduction in acquiring COVID-19 (95% CI = 0.80-0.94; p < 0.0001) and 13% reduction in hospitalization with COVID-19 (95% CI = 0.77-0.99, p = 0.03) for people with asthma compared with those without. There was no significant difference in the combined risk of requiring admission to ICU and/or receiving mechanical ventilation for people with asthma (RR = 0.87 95% CI = 0.94-1.37; p = 0.19) and risk of death from COVID-19 (RR = 0.87; 95% CI = 0.68-1.10; p = 0.25).

Conclusion

The findings from this study suggest that the prevalence of people with asthma among COVID-19 patients is similar to the global prevalence of asthma. The overall findings suggest that people with asthma have a lower risk than those without asthma for acquiring COVID-19 and have similar clinical outcomes.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/150429