Circadian Rhythm Disruption and Alzheimer's Disease: The Dynamics of a Vicious Cycle.

Sharma, A; Sethi, G; Tambuwala, MM; Aljabali, AAA; Chellappan, DK; Dua, K; Goyal, R

Circadian Rhythm Disruption and Alzheimer's Disease: The Dynamics of a Vicious Cycle.

Sharma, A Sethi, G Tambuwala, MM Aljabali, AAA Chellappan, DK Dua, K

Goyal, R

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Current neuropharmacology, 2021, 19, (2), pp. 248-264
Issue Date:: 2021-01-01

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Field	Value	Language
dc.contributor.author	Sharma, A
dc.contributor.author	Sethi, G
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Goyal, R
dc.date.accessioned	2021-09-13T03:29:30Z
dc.date.available	2020-04-24
dc.date.available	2021-09-13T03:29:30Z
dc.date.issued	2021-01-01
dc.identifier.citation	Current neuropharmacology, 2021, 19, (2), pp. 248-264
dc.identifier.issn	1570-159X
dc.identifier.issn	1875-6190
dc.identifier.uri	http://hdl.handle.net/10453/150509
dc.description.abstract	All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics. Autonomous cellular clocks are modulated by various pathways that are essential for robust time keeping. In addition to the canonical transcriptional translational feedback loop, several new pathways of circadian timekeeping - non-transcriptional oscillations, post-translational modifications, epigenetics and cellular signaling in the circadian clock - have been identified. The physiology of circadian rhythm is expansive, and its link to the neurodegeneration is multifactorial. Circadian rhythm disruption is prevelant in contamporary society where light-noise, shift-work, and transmeridian travel are commonplace, and is also reported from the early stages of Alzheimer's disease (AD). Circadian alignment by bright light therapy in conjunction with chronobiotics is beneficial for treating sundowning syndrome and other cognitive symptoms in advanced AD patients. We performed a comprehensive analysis of the clinical and translational reports to review the physiology of the circadian clock, delineate its dysfunction in AD, and unravel the dynamics of the vicious cycle between two pathologies. The review delineates the role of putative targets like clock proteins PER, CLOCK, BMAL1, ROR, and clock-controlled proteins like AVP, SIRT1, FOXO, and PK2 towards future approaches for management of AD. Furthermore, the role of circadian rhythm disruption in aging is delineated.
dc.format	Print
dc.language	eng
dc.publisher	Bentham Science Publishers Ltd.
dc.relation.ispartof	Current neuropharmacology
dc.relation.isbasedon	10.2174/1570159x18666200429013041
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1109 Neurosciences, 1115 Pharmacology and Pharmaceutical Sciences, 1701 Psychology
dc.subject.classification	Neurology & Neurosurgery
dc.title	Circadian Rhythm Disruption and Alzheimer's Disease: The Dynamics of a Vicious Cycle.
dc.type	Journal Article
utslib.citation.volume	19
utslib.location.activity	United Arab Emirates
utslib.for	1109 Neurosciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-09-13T03:29:25Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	19
utslib.citation.issue	2

Abstract:

All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics. Autonomous cellular clocks are modulated by various pathways that are essential for robust time keeping. In addition to the canonical transcriptional translational feedback loop, several new pathways of circadian timekeeping - non-transcriptional oscillations, post-translational modifications, epigenetics and cellular signaling in the circadian clock - have been identified. The physiology of circadian rhythm is expansive, and its link to the neurodegeneration is multifactorial. Circadian rhythm disruption is prevelant in contamporary society where light-noise, shift-work, and transmeridian travel are commonplace, and is also reported from the early stages of Alzheimer's disease (AD). Circadian alignment by bright light therapy in conjunction with chronobiotics is beneficial for treating sundowning syndrome and other cognitive symptoms in advanced AD patients. We performed a comprehensive analysis of the clinical and translational reports to review the physiology of the circadian clock, delineate its dysfunction in AD, and unravel the dynamics of the vicious cycle between two pathologies. The review delineates the role of putative targets like clock proteins PER, CLOCK, BMAL1, ROR, and clock-controlled proteins like AVP, SIRT1, FOXO, and PK2 towards future approaches for management of AD. Furthermore, the role of circadian rhythm disruption in aging is delineated.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/150509