Findings of Russian literature on the clinical application of Eleutherococcus senticosus (Rupr. & Maxim.): A narrative review.

Gerontakos, S; Taylor, A; Avdeeva, AY; Shikova, VA; Pozharitskaya, ON; Casteleijn, D; Wardle, J; Shikov, AN

Findings of Russian literature on the clinical application of Eleutherococcus senticosus (Rupr. & Maxim.): A narrative review.

Gerontakos, S Taylor, A Avdeeva, AY Shikova, VA Pozharitskaya, ON Casteleijn, D Wardle, J

Shikov, AN

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Journal of Ethnopharmacology, 2021, 278
Issue Date:: 2021-10

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Field	Value	Language
dc.contributor.author	Gerontakos, S
dc.contributor.author	Taylor, A
dc.contributor.author	Avdeeva, AY
dc.contributor.author	Shikova, VA
dc.contributor.author	Pozharitskaya, ON
dc.contributor.author	Casteleijn, D
dc.contributor.author	Wardle, J https://orcid.org/0000-0001-8813-3542
dc.contributor.author	Shikov, AN
dc.date.accessioned	2021-10-11T05:17:14Z
dc.date.available	2021-05-30
dc.date.available	2021-10-11T05:17:14Z
dc.date.issued	2021-10
dc.identifier.citation	Journal of Ethnopharmacology, 2021, 278
dc.identifier.issn	0378-8741
dc.identifier.issn	1872-7573
dc.identifier.uri	http://hdl.handle.net/10453/150995
dc.description.abstract	Aim of the review During the time of the USSR, a distinct research directive was undertaken on ES to examine substances which improve stamina and endurance, with over 1000 studies published. Due to security measures within the former USSR these papers were not accessible to the public and were never translated into English. This is the first study to make findings of the USSR studies on ES available to the international research and scientific community. Methods This study was an archival retrieval. References for studies were sought from printed journal and conference preceding's publications, then located within library catalogues of three libraries in St Petersburg Russia. Eligibility criteria included human clinical trials examining the efficacy of ES in any condition, published in the Russian language in the Soviet Union. Results A total of 46 studies published between 1962 and 1986 in the USSR were sourced. Of the retrieved articles, 29 were reported as placebo-controlled trials, 11 were reported as controlled trials and six studies did not report the study design. Trends in studies were those reporting on healthy volunteers (n=21) at a dose of 2 ml extract/day (n=14) examining outcomes such as physical and mental stamina under varying conditions, normal work conditions, high temperatures and high altitudes, incidence or prophylaxis of colds and influenza (n=5), effects on color perception and vision (n=2), work capacity (n=1), cognitive effects (n=1), prophylaxis of hearing loss (n=3), effects on blood cell counts (n=2) and sensitivity to UV radiation (n=1). Conclusions ES appears to exhibit benefits for cognitive function and physical and mental endurance and its effect as a respiratory system infection prophylaxis treatment are promising. This study is the first to publish the findings of clinical trials on ES from the USSR, which supports the traditional use and offers a valuable contribution to the body of evidence on medicinal uses of ES when the data is applied within the context of its limitations.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Journal of Ethnopharmacology
dc.relation.isbasedon	10.1016/j.jep.2021.114274
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0607 Plant Biology, 1104 Complementary and Alternative Medicine, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.title	Findings of Russian literature on the clinical application of Eleutherococcus senticosus (Rupr. & Maxim.): A narrative review.
dc.type	Journal Article
utslib.citation.volume	278
utslib.location.activity	Ireland
utslib.for	0607 Plant Biology
utslib.for	1104 Complementary and Alternative Medicine
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-10-11T05:17:13Z
pubs.publication-status	Published
pubs.volume	278

Abstract:

Aim of the review During the time of the USSR, a distinct research directive was undertaken on ES to examine substances which improve stamina and endurance, with over 1000 studies published. Due to security measures within the former USSR these papers were not accessible to the public and were never translated into English. This is the first study to make findings of the USSR studies on ES available to the international research and scientific community. Methods This study was an archival retrieval. References for studies were sought from printed journal and conference preceding's publications, then located within library catalogues of three libraries in St Petersburg Russia. Eligibility criteria included human clinical trials examining the efficacy of ES in any condition, published in the Russian language in the Soviet Union. Results A total of 46 studies published between 1962 and 1986 in the USSR were sourced. Of the retrieved articles, 29 were reported as placebo-controlled trials, 11 were reported as controlled trials and six studies did not report the study design. Trends in studies were those reporting on healthy volunteers (n=21) at a dose of 2 ml extract/day (n=14) examining outcomes such as physical and mental stamina under varying conditions, normal work conditions, high temperatures and high altitudes, incidence or prophylaxis of colds and influenza (n=5), effects on color perception and vision (n=2), work capacity (n=1), cognitive effects (n=1), prophylaxis of hearing loss (n=3), effects on blood cell counts (n=2) and sensitivity to UV radiation (n=1). Conclusions ES appears to exhibit benefits for cognitive function and physical and mental endurance and its effect as a respiratory system infection prophylaxis treatment are promising. This study is the first to publish the findings of clinical trials on ES from the USSR, which supports the traditional use and offers a valuable contribution to the body of evidence on medicinal uses of ES when the data is applied within the context of its limitations.

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http://hdl.handle.net/10453/150995