High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition

Nankali, M; Einalou, Z; Asadnia, M; Razmjou, A

High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition

Nankali, M Einalou, Z Asadnia, M Razmjou, A

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Publisher:: American Chemical Society (ACS)
Publication Type:: Journal Article
Citation:: ACS Applied Bio Materials, 2021, 4, (2), pp. 1958-1968
Issue Date:: 2021-02-15

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Field	Value	Language
dc.contributor.author	Nankali, M
dc.contributor.author	Einalou, Z
dc.contributor.author	Asadnia, M
dc.contributor.author	Razmjou, A
dc.date.accessioned	2021-10-20T05:48:49Z
dc.date.available	2021-10-20T05:48:49Z
dc.date.issued	2021-02-15
dc.identifier.citation	ACS Applied Bio Materials, 2021, 4, (2), pp. 1958-1968
dc.identifier.issn	2576-6422
dc.identifier.issn	2576-6422
dc.identifier.uri	http://hdl.handle.net/10453/151181
dc.description.abstract	Optical biosensors are sensitive devices used in bioanalytics detection. Analysis of blood constituents is very important for the detection of major diseases and also performs a significant role in the diagnosis of diabetes, various cancers, and cardiovascular disorders. In this work, a three-dimensional photonic crystal-based biosensor composed of zeolitic imidazolate framework-8 (ZIF-8) nanoarrays are placed on polydopamine (PDA) coated on a silicon substrate. This sensor is designed, simulated, and evaluated for various blood components in the wavelength range of 1.1 to 1.5 μm by the finite-difference time-domain (FDTD) method. The proposed biosensor was used for 10 types of blood components such as biotin-streptavidin, bovine serum albumin (BSA), cytop, glucose (40 mg/100 mL), hemoglobin, blood plasma, Sylgard184, white blood compounds, urethane dimethacrylate, and polyacrylamide. The FDTD technique was used for the performance analysis of the biosensor. The design parameters of the radius, the lattice constant, the thickness of the ZIF-8 arrays, and the PDA layer thickness are chosen to optimize the photonic crystal structure. This study indicates that the thickness of the PDA is the most important parameter for peak wavelength value in comparison to the other physical parameters. The factors for optimizing the photonic crystal-based biosensors such as the peak wavelength value (PWV), sensitivity, full width at half-maximum (FWHM), and figure of merit (FOM) are significant in comparison with pertinent works in this field, which evaluated 171 nm/RIU, 7.62 nm, and 22.5 RIU-1, respectively. A change of 0.01 nm in the refractive index of the constituents of the blood leads to a shift of 80 nm in the maximum peak wavelength, therefore acting as a functional biosensor with a high detection limit of 0.004 RIU.
dc.language	en
dc.publisher	American Chemical Society (ACS)
dc.relation.ispartof	ACS Applied Bio Materials
dc.relation.isbasedon	10.1021/acsabm.0c01586
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition
dc.type	Journal Article
utslib.citation.volume	4
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2021-10-20T05:48:47Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	4
utslib.citation.issue	2

Abstract:

Optical biosensors are sensitive devices used in bioanalytics detection. Analysis of blood constituents is very important for the detection of major diseases and also performs a significant role in the diagnosis of diabetes, various cancers, and cardiovascular disorders. In this work, a three-dimensional photonic crystal-based biosensor composed of zeolitic imidazolate framework-8 (ZIF-8) nanoarrays are placed on polydopamine (PDA) coated on a silicon substrate. This sensor is designed, simulated, and evaluated for various blood components in the wavelength range of 1.1 to 1.5 μm by the finite-difference time-domain (FDTD) method. The proposed biosensor was used for 10 types of blood components such as biotin-streptavidin, bovine serum albumin (BSA), cytop, glucose (40 mg/100 mL), hemoglobin, blood plasma, Sylgard184, white blood compounds, urethane dimethacrylate, and polyacrylamide. The FDTD technique was used for the performance analysis of the biosensor. The design parameters of the radius, the lattice constant, the thickness of the ZIF-8 arrays, and the PDA layer thickness are chosen to optimize the photonic crystal structure. This study indicates that the thickness of the PDA is the most important parameter for peak wavelength value in comparison to the other physical parameters. The factors for optimizing the photonic crystal-based biosensors such as the peak wavelength value (PWV), sensitivity, full width at half-maximum (FWHM), and figure of merit (FOM) are significant in comparison with pertinent works in this field, which evaluated 171 nm/RIU, 7.62 nm, and 22.5 RIU-1, respectively. A change of 0.01 nm in the refractive index of the constituents of the blood leads to a shift of 80 nm in the maximum peak wavelength, therefore acting as a functional biosensor with a high detection limit of 0.004 RIU.

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http://hdl.handle.net/10453/151181