Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study

Gelaw, B; Mulatu, G; Tesfa, G; Marew, C; Chekole, B; Alebel, A

Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study

Gelaw, B Mulatu, G Tesfa, G Marew, C Chekole, B Alebel, A

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Publisher:: BioMed Central
Publication Type:: Journal Article
Citation:: Italian Journal of Paediatrics, 2021, 47, (1)
Issue Date:: 2021-04-06

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Field	Value	Language
dc.contributor.author	Gelaw, B
dc.contributor.author	Mulatu, G
dc.contributor.author	Tesfa, G
dc.contributor.author	Marew, C
dc.contributor.author	Chekole, B
dc.contributor.author	Alebel, A
dc.date.accessioned	2021-11-11T04:17:07Z
dc.date.available	2021-03-15
dc.date.available	2021-11-11T04:17:07Z
dc.date.issued	2021-04-06
dc.identifier.citation	Italian Journal of Paediatrics, 2021, 47, (1)
dc.identifier.issn	1720-8424
dc.identifier.issn	1824-7288
dc.identifier.uri	http://hdl.handle.net/10453/151505
dc.description.abstract	Background Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and develop public health interventions in children receiving antiretroviral therapy. Thus, this study aims to assess the magnitude and associated factors of virological failure among children on antiretroviral therapy. Methods A facility-based cross-sectional study was conducted among 399 HIV-positive children on antiretroviral therapy from 2016 to 2019 in Bahir Dar Town public health facilities. Data were extracted from children’s charts using a standardized data extraction tool, adapted from ART intake and follow-up forms. Data were entered using Epi-Data Version 3.1, and analyzed using SPSS Version 25. Bivariable and multivariable binary logistic regression models were done to identify factors associated with virological failure. Variables with p-values < 0.25 were fitted into the multivariable analysis. Finally, variables with p-values <0.05 were considered as statistically significant factors. Results The period prevalence of virological failure was found to be 14.8% (95% CI: 11.5–19.3%). Opportunistic infections (AOR = 2.19, CI: 1.13–4.25), history of treatment interruption and restart (AOR = 2.21, CI: 1.09–4.54), younger age (AOR = 2.42, CI: 1.02–5.74), poor/fair ART adherence (AOR = 2.19, CI: 1.05–4.57), and advanced baseline WHO clinical staging (AOR = 2.32, CI: 1.14–4.74) were found to be factors significantly associated with virological failure. Conclusion The magnitude of virological failure among HIV-infected children remained high. Children with poor/fair ART adherence, history of treatment interruption, advanced baseline WHO clinical staging, younger age, and opportunistic infections were significantly associated with virologic failure. Thus, special attention should be given to children who had poor/fair ART adherence and presenting with opportunistic infections.
dc.format	Electronic
dc.language	eng
dc.publisher	BioMed Central
dc.relation.ispartof	Italian Journal of Paediatrics
dc.relation.isbasedon	10.1186/s13052-021-01030-7
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1114 Paediatrics and Reproductive Medicine
dc.subject.classification	Pediatrics
dc.subject.mesh	Adolescent
dc.subject.mesh	Age Factors
dc.subject.mesh	Anti-Retroviral Agents
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Ethiopia
dc.subject.mesh	Female
dc.subject.mesh	HIV Infections
dc.subject.mesh	Humans
dc.subject.mesh	Infant
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Male
dc.subject.mesh	Medication Adherence
dc.subject.mesh	Opportunistic Infections
dc.subject.mesh	Treatment Failure
dc.subject.mesh	Viral Load
dc.title	Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study
dc.type	Journal Article
utslib.citation.volume	47
utslib.location.activity	England
utslib.for	1114 Paediatrics and Reproductive Medicine
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2021-11-11T04:17:06Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	47
utslib.citation.issue	1

Abstract:

Background Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and develop public health interventions in children receiving antiretroviral therapy. Thus, this study aims to assess the magnitude and associated factors of virological failure among children on antiretroviral therapy. Methods A facility-based cross-sectional study was conducted among 399 HIV-positive children on antiretroviral therapy from 2016 to 2019 in Bahir Dar Town public health facilities. Data were extracted from children’s charts using a standardized data extraction tool, adapted from ART intake and follow-up forms. Data were entered using Epi-Data Version 3.1, and analyzed using SPSS Version 25. Bivariable and multivariable binary logistic regression models were done to identify factors associated with virological failure. Variables with p-values < 0.25 were fitted into the multivariable analysis. Finally, variables with p-values <0.05 were considered as statistically significant factors. Results The period prevalence of virological failure was found to be 14.8% (95% CI: 11.5–19.3%). Opportunistic infections (AOR = 2.19, CI: 1.13–4.25), history of treatment interruption and restart (AOR = 2.21, CI: 1.09–4.54), younger age (AOR = 2.42, CI: 1.02–5.74), poor/fair ART adherence (AOR = 2.19, CI: 1.05–4.57), and advanced baseline WHO clinical staging (AOR = 2.32, CI: 1.14–4.74) were found to be factors significantly associated with virological failure. Conclusion The magnitude of virological failure among HIV-infected children remained high. Children with poor/fair ART adherence, history of treatment interruption, advanced baseline WHO clinical staging, younger age, and opportunistic infections were significantly associated with virologic failure. Thus, special attention should be given to children who had poor/fair ART adherence and presenting with opportunistic infections.

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http://hdl.handle.net/10453/151505