Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne

Bisht, A; Hemrajani, C; Rathore, C; Dhiman, T; Rolta, R; Upadhyay, N; Nidhi, P; Gupta, G; Dua, K; Chellappan, DK; Dev, K; Sourirajan, A; Chakraborty, A; Aljabali, AAA; Bakshi, HA; Negi, P; Tambuwala, MM

Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne

Bisht, A Hemrajani, C Rathore, C Dhiman, T Rolta, R Upadhyay, N Nidhi, P Gupta, G Dua, K

Chellappan, DK Dev, K Sourirajan, A Chakraborty, A Aljabali, AAA Bakshi, HA Negi, P Tambuwala, MM

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Drug Delivery and Translational Research

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Field	Value	Language
dc.contributor.author	Bisht, A
dc.contributor.author	Hemrajani, C
dc.contributor.author	Rathore, C
dc.contributor.author	Dhiman, T
dc.contributor.author	Rolta, R
dc.contributor.author	Upadhyay, N
dc.contributor.author	Nidhi, P
dc.contributor.author	Gupta, G
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dev, K
dc.contributor.author	Sourirajan, A
dc.contributor.author	Chakraborty, A
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Bakshi, HA
dc.contributor.author	Negi, P
dc.contributor.author	Tambuwala, MM
dc.date.accessioned	2021-11-16T05:40:45Z
dc.date.available	2021-11-16T05:40:45Z
dc.identifier.citation	Drug Delivery and Translational Research
dc.identifier.issn	2190-393X
dc.identifier.issn	2190-3948
dc.identifier.uri	http://hdl.handle.net/10453/151632
dc.description.abstract	<jats:title>Abstract</jats:title><jats:p>Azelaic acid (AzA) is a USFDA bioactive prescribed against <jats:italic>acne vulgaris</jats:italic>. It possesses delivery challenges like poor aqueous solubility, low skin-penetrability, and dose-dependent side effects, which could be overcome by its synergistic combination with tea tree oil (TTO) as a microemulsion (ME)-based hydrogel composite. AzA-TTO ME was prepared to employ pseudo-ternary phase diagram construction. The best AzA-TTO ME was of uniform size (polydispersity index < 0.7), nano-range (~357.4 ± 2% nm), transmittance (> 90%), and negative zeta potential (−1.42 ± 0.25% mV) values. ME hydrogel composite with optimum rheological and textural attributes showed better permeation, retention, and skin-compliant characteristics, vis-a-vis marketed formulation (Aziderm™) when evaluated in Wistar rat skin. In vitro antibacterial efficacy in bacterial strains, i.e., <jats:italic>Staphylococcus aureus</jats:italic>, <jats:italic>Propionibacterium acne</jats:italic>, and <jats:italic>Staphylococcus epidermidis</jats:italic>, was evaluated employing agar well plate diffusion and broth dilution assay. ME hydrogel has shown an increase in zone of inhibition by two folds and a decrease in minimum inhibitory concentration (MIC) by eightfold against <jats:italic>P. acnes</jats:italic> vis-a-vis AzA. Finally, ME hydrogel composite exhibited a better reduction in the papule density (93.75 ± 1.64%) in comparison to Aziderm™ 72.69 ± 4.67%) on acne as developed in rats by inducing testosterone. Thus, the developed AzA-TTO ME hydrogel composite promises an efficacious and comparatively safer drug delivery system for the topical therapy of <jats:italic>acne vulgaris</jats:italic>.</jats:p> <jats:p><jats:bold>Graphical abstract</jats:bold></jats:p>
dc.language	en
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Drug Delivery and Translational Research
dc.relation.isbasedon	10.1007/s13346-021-01092-4
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.title	Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne
dc.type	Journal Article
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2021-11-16T05:40:43Z
pubs.publication-status	Published online

Abstract:

AbstractAzelaic acid (AzA) is a USFDA bioactive prescribed against acne vulgaris. It possesses delivery challenges like poor aqueous solubility, low skin-penetrability, and dose-dependent side effects, which could be overcome by its synergistic combination with tea tree oil (TTO) as a microemulsion (ME)-based hydrogel composite. AzA-TTO ME was prepared to employ pseudo-ternary phase diagram construction. The best AzA-TTO ME was of uniform size (polydispersity index < 0.7), nano-range (~357.4 ± 2% nm), transmittance (> 90%), and negative zeta potential (−1.42 ± 0.25% mV) values. ME hydrogel composite with optimum rheological and textural attributes showed better permeation, retention, and skin-compliant characteristics, vis-a-vis marketed formulation (Aziderm™) when evaluated in Wistar rat skin. In vitro antibacterial efficacy in bacterial strains, i.e., Staphylococcus aureus, Propionibacterium acne, and Staphylococcus epidermidis, was evaluated employing agar well plate diffusion and broth dilution assay. ME hydrogel has shown an increase in zone of inhibition by two folds and a decrease in minimum inhibitory concentration (MIC) by eightfold against P. acnes vis-a-vis AzA. Finally, ME hydrogel composite exhibited a better reduction in the papule density (93.75 ± 1.64%) in comparison to Aziderm™ 72.69 ± 4.67%) on acne as developed in rats by inducing testosterone. Thus, the developed AzA-TTO ME hydrogel composite promises an efficacious and comparatively safer drug delivery system for the topical therapy of acne vulgaris. Graphical abstract

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http://hdl.handle.net/10453/151632