Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne

Bisht, A; Hemrajani, C; Upadhyay, N; Nidhi, P; Rolta, R; Rathore, C; Gupta, G; Dua, K; Chellappan, DK; Dev, K; Sourirajan, A; Aljabali, AAA; Bakshi, HA; Negi, P; Tambuwala, MM

Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne

Bisht, A Hemrajani, C Upadhyay, N Nidhi, P Rolta, R Rathore, C Gupta, G Dua, K

Chellappan, DK Dev, K Sourirajan, A Aljabali, AAA Bakshi, HA Negi, P Tambuwala, MM

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Publisher:: Future Science Ltd
Publication Type:: Journal Article
Citation:: Therapeutic Delivery

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Field	Value	Language
dc.contributor.author	Bisht, A
dc.contributor.author	Hemrajani, C
dc.contributor.author	Upadhyay, N
dc.contributor.author	Nidhi, P
dc.contributor.author	Rolta, R
dc.contributor.author	Rathore, C
dc.contributor.author	Gupta, G
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dev, K
dc.contributor.author	Sourirajan, A
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Bakshi, HA
dc.contributor.author	Negi, P
dc.contributor.author	Tambuwala, MM
dc.date.accessioned	2021-11-30T06:08:22Z
dc.date.available	2021-11-30T06:08:22Z
dc.identifier.citation	Therapeutic Delivery
dc.identifier.issn	2041-5990
dc.identifier.issn	2041-6008
dc.identifier.uri	http://hdl.handle.net/10453/151929
dc.description.abstract	<jats:p> Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management. </jats:p>
dc.language	en
dc.publisher	Future Science Ltd
dc.relation.ispartof	Therapeutic Delivery
dc.relation.isbasedon	10.4155/tde-2021-0059
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0903 Biomedical Engineering, 1004 Medical Biotechnology, 1115 Pharmacology and Pharmaceutical Sciences
dc.title	Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne
dc.type	Journal Article
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2022-11-29T00:00:00+1000Z
dc.date.updated	2021-11-30T06:08:17Z
pubs.publication-status	Published online

Abstract:

Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/151929