Outcomes and measures of delirium interventional studies in palliative care to inform a core outcome set: A systematic review.

Agar, MR; Siddiqi, N; Hosie, A; Boland, JW; Johnson, MJ; Featherstone, I; Lawlor, PG; Bush, SH; Page, V; Amgarth-Duff, I; Garcia, M; Disalvo, D; Rose, L; Del-COrS Group,

Outcomes and measures of delirium interventional studies in palliative care to inform a core outcome set: A systematic review.

Agar, MR Siddiqi, N Hosie, A

Boland, JW Johnson, MJ Featherstone, I Lawlor, PG Bush, SH Page, V Amgarth-Duff, I Garcia, M

Disalvo, D Rose, L Del-COrS Group,

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Publisher:: SAGE Publications
Publication Type:: Journal Article
Citation:: Palliative Medicine, 2021, 35, (10), pp. 1761-1775
Issue Date:: 2021-12

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Field	Value	Language
dc.contributor.author	Agar, MR
dc.contributor.author	Siddiqi, N
dc.contributor.author	Hosie, A https://orcid.org/0000-0003-1674-2124
dc.contributor.author	Boland, JW
dc.contributor.author	Johnson, MJ
dc.contributor.author	Featherstone, I
dc.contributor.author	Lawlor, PG
dc.contributor.author	Bush, SH
dc.contributor.author	Page, V
dc.contributor.author	Amgarth-Duff, I
dc.contributor.author	Garcia, M https://orcid.org/0000-0002-9496-9546
dc.contributor.author	Disalvo, D
dc.contributor.author	Rose, L
dc.contributor.author	Del-COrS Group,
dc.date.accessioned	2021-12-17T01:01:22Z
dc.date.available	2021-12-17T01:01:22Z
dc.date.issued	2021-12
dc.identifier.citation	Palliative Medicine, 2021, 35, (10), pp. 1761-1775
dc.identifier.issn	0269-2163
dc.identifier.issn	1477-030X
dc.identifier.uri	http://hdl.handle.net/10453/152376
dc.description.abstract	Background: Trials of interventions for delirium in various patient populations report disparate outcomes and measures but little is known about those used in palliative care trials. A core outcome set promotes consistency of outcome selection and measurement. Aim: To inform core outcome set development by examining outcomes, their definitions, measures and time-points in published palliative care studies of delirium prevention or treatment delirium interventions. Design: Prospectively registered systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Data sources: We searched six electronic databases (1980–November 2020) for original studies, three for relevant reviews and the International Clinical Trials Registry Platform for unpublished studies and ongoing trials. We included randomised, quasi-randomised and non-randomised intervention studies of pharmacological and non-pharmacological delirium prevention and/or treatment interventions. Results: From 13/3244 studies (2863 adult participants), we identified 9 delirium-specific and 13 non-delirium specific outcome domains within eight Core Outcome Measures in Effectiveness Trials (COMET) taxonomy categories. There were multiple and varied outcomes and time points in each domain. The commonest delirium specific outcome was delirium severity (n = 7), commonly using the Memorial Delirium Assessment Scale (6/8 studies, 75%). Four studies reported delirium incidence. Non-delirium specific outcomes included mortality, agitation, adverse events, other symptoms and quality of life. Conclusion: The review identified few delirium interventions with heterogeneity in outcomes, their definition and measurement, highlighting the need for a uniform approach. Findings will inform the next stage to develop consensus for a core outcome set to inform delirium interventional palliative care research.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SAGE Publications
dc.relation.ispartof	Palliative Medicine
dc.relation.isbasedon	10.1177/02692163211040186
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1117 Public Health and Health Services, 1199 Other Medical and Health Sciences
dc.subject.classification	Gerontology
dc.title	Outcomes and measures of delirium interventional studies in palliative care to inform a core outcome set: A systematic review.
dc.type	Journal Article
utslib.citation.volume	35
utslib.location.activity	England
utslib.for	1117 Public Health and Health Services
utslib.for	1199 Other Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-12-17T01:01:21Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	35
utslib.citation.issue	10

Abstract:

Background: Trials of interventions for delirium in various patient populations report disparate outcomes and measures but little is known about those used in palliative care trials. A core outcome set promotes consistency of outcome selection and measurement. Aim: To inform core outcome set development by examining outcomes, their definitions, measures and time-points in published palliative care studies of delirium prevention or treatment delirium interventions. Design: Prospectively registered systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Data sources: We searched six electronic databases (1980–November 2020) for original studies, three for relevant reviews and the International Clinical Trials Registry Platform for unpublished studies and ongoing trials. We included randomised, quasi-randomised and non-randomised intervention studies of pharmacological and non-pharmacological delirium prevention and/or treatment interventions. Results: From 13/3244 studies (2863 adult participants), we identified 9 delirium-specific and 13 non-delirium specific outcome domains within eight Core Outcome Measures in Effectiveness Trials (COMET) taxonomy categories. There were multiple and varied outcomes and time points in each domain. The commonest delirium specific outcome was delirium severity (n = 7), commonly using the Memorial Delirium Assessment Scale (6/8 studies, 75%). Four studies reported delirium incidence. Non-delirium specific outcomes included mortality, agitation, adverse events, other symptoms and quality of life. Conclusion: The review identified few delirium interventions with heterogeneity in outcomes, their definition and measurement, highlighting the need for a uniform approach. Findings will inform the next stage to develop consensus for a core outcome set to inform delirium interventional palliative care research.

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http://hdl.handle.net/10453/152376