Autism-related dietary preferences mediate autism-gut microbiome associations.

Yap, CX; Henders, AK; Alvares, GA; Wood, DLA; Krause, L; Tyson, GW; Restuadi, R; Wallace, L; McLaren, T; Hansell, NK; Cleary, D; Grove, R; Hafekost, C; Harun, A; Holdsworth, H; Jellett, R; Khan, F; Lawson, LP; Leslie, J; Frenk, ML; Masi, A; Mathew, NE; Muniandy, M; Nothard, M; Miller, JL; Nunn, L; Holtmann, G; Strike, LT; de Zubicaray, GI; Thompson, PM; McMahon, KL; Wright, MJ; Visscher, PM; Dawson, PA; Dissanayake, C; Eapen, V; Heussler, HS; McRae, AF; Whitehouse, AJO; Wray, NR; Gratten, J

Autism-related dietary preferences mediate autism-gut microbiome associations.

Yap, CX Henders, AK Alvares, GA Wood, DLA Krause, L Tyson, GW Restuadi, R Wallace, L McLaren, T Hansell, NK Cleary, D Grove, R

Hafekost, C Harun, A Holdsworth, H Jellett, R Khan, F Lawson, LP Leslie, J Frenk, ML Masi, A Mathew, NE Muniandy, M Nothard, M Miller, JL Nunn, L Holtmann, G Strike, LT de Zubicaray, GI Thompson, PM McMahon, KL Wright, MJ Visscher, PM Dawson, PA Dissanayake, C Eapen, V Heussler, HS McRae, AF Whitehouse, AJO Wray, NR Gratten, J

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Cell, 2021, 184, (24), pp. 5916-5931.e17
Issue Date:: 2021-11-11

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Field	Value	Language
dc.contributor.author	Yap, CX
dc.contributor.author	Henders, AK
dc.contributor.author	Alvares, GA
dc.contributor.author	Wood, DLA
dc.contributor.author	Krause, L
dc.contributor.author	Tyson, GW
dc.contributor.author	Restuadi, R
dc.contributor.author	Wallace, L
dc.contributor.author	McLaren, T
dc.contributor.author	Hansell, NK
dc.contributor.author	Cleary, D
dc.contributor.author	Grove, R https://orcid.org/0000-0001-6669-9385
dc.contributor.author	Hafekost, C
dc.contributor.author	Harun, A
dc.contributor.author	Holdsworth, H
dc.contributor.author	Jellett, R
dc.contributor.author	Khan, F
dc.contributor.author	Lawson, LP
dc.contributor.author	Leslie, J
dc.contributor.author	Frenk, ML
dc.contributor.author	Masi, A
dc.contributor.author	Mathew, NE
dc.contributor.author	Muniandy, M
dc.contributor.author	Nothard, M
dc.contributor.author	Miller, JL
dc.contributor.author	Nunn, L
dc.contributor.author	Holtmann, G
dc.contributor.author	Strike, LT
dc.contributor.author	de Zubicaray, GI
dc.contributor.author	Thompson, PM
dc.contributor.author	McMahon, KL
dc.contributor.author	Wright, MJ
dc.contributor.author	Visscher, PM
dc.contributor.author	Dawson, PA
dc.contributor.author	Dissanayake, C
dc.contributor.author	Eapen, V
dc.contributor.author	Heussler, HS
dc.contributor.author	McRae, AF
dc.contributor.author	Whitehouse, AJO
dc.contributor.author	Wray, NR
dc.contributor.author	Gratten, J
dc.date.accessioned	2021-12-28T23:08:53Z
dc.date.available	2021-10-13
dc.date.available	2021-12-28T23:08:53Z
dc.date.issued	2021-11-11
dc.identifier.citation	Cell, 2021, 184, (24), pp. 5916-5931.e17
dc.identifier.issn	0092-8674
dc.identifier.issn	1097-4172
dc.identifier.uri	http://hdl.handle.net/10453/152551
dc.description.abstract	There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive way. We performed a large autism stool metagenomics study (n = 247) based on participants from the Australian Autism Biobank and the Queensland Twin Adolescent Brain project. We found negligible direct associations between ASD diagnosis and the gut microbiome. Instead, our data support a model whereby ASD-related restricted interests are associated with less-diverse diet, and in turn reduced microbial taxonomic diversity and looser stool consistency. In contrast to ASD diagnosis, our dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency. Overall, microbiome differences in ASD may reflect dietary preferences that relate to diagnostic features, and we caution against claims that the microbiome has a driving role in ASD.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Cell
dc.relation.isbasedon	10.1016/j.cell.2021.10.015
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.classification	Developmental Biology
dc.title	Autism-related dietary preferences mediate autism-gut microbiome associations.
dc.type	Journal Article
utslib.citation.volume	184
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
dc.date.updated	2021-12-28T23:08:49Z
pubs.issue	24
pubs.publication-status	Published
pubs.volume	184
utslib.citation.issue	24

Abstract:

There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive way. We performed a large autism stool metagenomics study (n = 247) based on participants from the Australian Autism Biobank and the Queensland Twin Adolescent Brain project. We found negligible direct associations between ASD diagnosis and the gut microbiome. Instead, our data support a model whereby ASD-related restricted interests are associated with less-diverse diet, and in turn reduced microbial taxonomic diversity and looser stool consistency. In contrast to ASD diagnosis, our dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency. Overall, microbiome differences in ASD may reflect dietary preferences that relate to diagnostic features, and we caution against claims that the microbiome has a driving role in ASD.

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http://hdl.handle.net/10453/152551