Gastric ulcer healing by chebulinic acid solid dispersion-loaded gastroretentive raft systems: preclinical evidence

Negi, P; Gautam, S; Sharma, A; Rathore, C; Sharma, L; Upadhyay, N; Tambuwala, MM; Chellappan, DK; Gupta, G; Prasher, P; Dua, K; Agarwal, S; Lal, UR

Gastric ulcer healing by chebulinic acid solid dispersion-loaded gastroretentive raft systems: preclinical evidence

Negi, P Gautam, S Sharma, A Rathore, C Sharma, L Upadhyay, N Tambuwala, MM Chellappan, DK Gupta, G Prasher, P Dua, K

Agarwal, S Lal, UR

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Publisher:: Future Science Ltd
Publication Type:: Journal Article
Citation:: Therapeutic Delivery

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Field	Value	Language
dc.contributor.author	Negi, P
dc.contributor.author	Gautam, S
dc.contributor.author	Sharma, A
dc.contributor.author	Rathore, C
dc.contributor.author	Sharma, L
dc.contributor.author	Upadhyay, N
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Prasher, P
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Agarwal, S
dc.contributor.author	Lal, UR
dc.date.accessioned	2022-01-28T01:29:53Z
dc.date.available	2022-01-28T01:29:53Z
dc.identifier.citation	Therapeutic Delivery
dc.identifier.issn	2041-5990
dc.identifier.issn	2041-6008
dc.identifier.uri	http://hdl.handle.net/10453/153719
dc.description.abstract	<jats:p> Background: Chebulinic acid (CA), a component in Terminalia chebula, exhibits antiulcer activity, but has poor aqueous solubility. Raft-forming systems incorporating solid dispersions (SDs) of CA, were developed to overcome its poor biopharmaceutical properties and to prolong the gastric residence time for maximum activity. Methods: SDs were formulated by a solvent evaporation method using Eudragit EPO. Raft formulations consisted of sodium alginate as a polymer. Results: Release of CA in the dissolution medium was 40%, whereas SDs showed 95.45% release. The CA raft system (20 mg/kg) showed curative efficacy in an alcohol-induced gastric ulcer model and increased protection when compared with omeprazole (10 mg/kg) and CA suspension (20 mg/kg). Conclusion: These studies demonstrated SD raft systems to be a promising approach for antiulcer therapy by CA. </jats:p>
dc.language	en
dc.publisher	Future Science Ltd
dc.relation.ispartof	Therapeutic Delivery
dc.relation.isbasedon	10.4155/tde-2021-0062
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0903 Biomedical Engineering, 1004 Medical Biotechnology, 1115 Pharmacology and Pharmaceutical Sciences
dc.title	Gastric ulcer healing by chebulinic acid solid dispersion-loaded gastroretentive raft systems: preclinical evidence
dc.type	Journal Article
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2022-01-28T01:29:50Z
pubs.publication-status	Published online

Abstract:

Background: Chebulinic acid (CA), a component in Terminalia chebula, exhibits antiulcer activity, but has poor aqueous solubility. Raft-forming systems incorporating solid dispersions (SDs) of CA, were developed to overcome its poor biopharmaceutical properties and to prolong the gastric residence time for maximum activity. Methods: SDs were formulated by a solvent evaporation method using Eudragit EPO. Raft formulations consisted of sodium alginate as a polymer. Results: Release of CA in the dissolution medium was 40%, whereas SDs showed 95.45% release. The CA raft system (20 mg/kg) showed curative efficacy in an alcohol-induced gastric ulcer model and increased protection when compared with omeprazole (10 mg/kg) and CA suspension (20 mg/kg). Conclusion: These studies demonstrated SD raft systems to be a promising approach for antiulcer therapy by CA.

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http://hdl.handle.net/10453/153719