Weight change after antiretroviral therapy initiation among adults living with HIV in Northwest Ethiopia: a longitudinal data analysis

Alebel, A; Demant, D; Petrucka, PM; Sibbritt, D

Weight change after antiretroviral therapy initiation among adults living with HIV in Northwest Ethiopia: a longitudinal data analysis

Alebel, A Demant, D

Petrucka, PM Sibbritt, D

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Publisher:: BMJ
Publication Type:: Journal Article
Citation:: BMJ Open, 2022, 12, (2), pp. e055266-e055266
Issue Date:: 2022-02

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Field	Value	Language
dc.contributor.author	Alebel, A
dc.contributor.author	Demant, D https://orcid.org/0000-0003-3330-2972
dc.contributor.author	Petrucka, PM
dc.contributor.author	Sibbritt, D
dc.date.accessioned	2022-02-02T01:40:43Z
dc.date.available	2022-02-02T01:40:43Z
dc.date.issued	2022-02
dc.identifier.citation	BMJ Open, 2022, 12, (2), pp. e055266-e055266
dc.identifier.issn	2044-6055
dc.identifier.issn	2044-6055
dc.identifier.uri	http://hdl.handle.net/10453/154082
dc.description.abstract	<jats:sec><jats:title>Objectives</jats:title><jats:p>The first objective was to explore weight change in the first 2 years after antiretroviral therapy (ART) initiation in adults living with HIV. The second objective was to identify the predictors of weight change over time among adults living with HIV on ART.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>An institution-based retrospective longitudinal study was conducted.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>The study was conducted at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>The study included 848 randomly selected medical charts of adults living with HIV receiving ART between June 2014 and June 2020.</jats:p></jats:sec><jats:sec><jats:title>Primary and secondary outcomes</jats:title><jats:p>The primary outcome was weight change in the first 2 years after ART initiation. The secondary outcome was to identify predictors of weight change. Association between predictor variables and weight change was assessed using an LMM. Variables with p values <0.05 in the final model were considered as statistically significant predictors of weight change.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 844 study participants, more than half (n=499; 58.8%) were female. Participants’ mean weight increased from 54.2 kg (SD ±9.6 kg) at baseline to 59.5 kg (SD ±10.7 kg) at the end of follow-up. Duration of time on ART, sex, WHO clinical disease staging, functional status, nutritional status and presence of opportunistic infections were significant predictors of weight change at ART initiation. Significant interaction effects were observed between time and sex, WHO clinical disease staging, functional status, isoniazid preventive therapy and nutritional status.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>We found a linear increment of weight over 24 months of follow-up. Rate of weight gain over time was lower in patients with advanced disease stage and working functional status, whereas weight gain rate was higher in male and underweight patients.</jats:p></jats:sec>
dc.language	en
dc.publisher	BMJ
dc.relation.ispartof	BMJ Open
dc.relation.isbasedon	10.1136/bmjopen-2021-055266
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1103 Clinical Sciences, 1117 Public Health and Health Services, 1199 Other Medical and Health Sciences
dc.title	Weight change after antiretroviral therapy initiation among adults living with HIV in Northwest Ethiopia: a longitudinal data analysis
dc.type	Journal Article
utslib.citation.volume	12
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
utslib.for	1199 Other Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	recently_added	*
dc.date.updated	2022-02-02T01:40:42Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	2

Abstract:

ObjectivesThe first objective was to explore weight change in the first 2 years after antiretroviral therapy (ART) initiation in adults living with HIV. The second objective was to identify the predictors of weight change over time among adults living with HIV on ART.DesignAn institution-based retrospective longitudinal study was conducted.SettingThe study was conducted at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia.ParticipantsThe study included 848 randomly selected medical charts of adults living with HIV receiving ART between June 2014 and June 2020.Primary and secondary outcomesThe primary outcome was weight change in the first 2 years after ART initiation. The secondary outcome was to identify predictors of weight change. Association between predictor variables and weight change was assessed using an LMM. Variables with p values <0.05 in the final model were considered as statistically significant predictors of weight change.ResultsOf 844 study participants, more than half (n=499; 58.8%) were female. Participants’ mean weight increased from 54.2 kg (SD ±9.6 kg) at baseline to 59.5 kg (SD ±10.7 kg) at the end of follow-up. Duration of time on ART, sex, WHO clinical disease staging, functional status, nutritional status and presence of opportunistic infections were significant predictors of weight change at ART initiation. Significant interaction effects were observed between time and sex, WHO clinical disease staging, functional status, isoniazid preventive therapy and nutritional status.ConclusionWe found a linear increment of weight over 24 months of follow-up. Rate of weight gain over time was lower in patients with advanced disease stage and working functional status, whereas weight gain rate was higher in male and underweight patients.

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http://hdl.handle.net/10453/154082