Loss of miRNA biogenesis induces p19(Arf)-p53 signaling and senescence in primary cells

Publisher:
Rockefeller Univ Press
Publication Type:
Journal Article
Citation:
Journal Of Cell Biology, 2008, 181 (7), pp. 1055 - 1063
Issue Date:
2008-01
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Dicer, an enzyme involved in microRNA (miRNA) maturation, is required for proper cell differentiation and embryogenesis in mammals. Recent evidence indicates that Dicer and miRNA may also regulate tumorigenesis. To better characterize the role of miRNA i
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