Argonaute proteins: Key players in RNA silencing

Hutvagner, G; Simard, MJ

Argonaute proteins: Key players in RNA silencing

Hutvagner, G

Simard, MJ

Permalink

Publication Type:: Journal Article
Citation:: Nature Reviews Molecular Cell Biology, 2008, 9 (1), pp. 22 - 32
Issue Date:: 2008-01-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (182.72 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.contributor.author	Simard, MJ	en_US
dc.date.issued	2008-01-01	en_US
dc.identifier.citation	Nature Reviews Molecular Cell Biology, 2008, 9 (1), pp. 22 - 32	en_US
dc.identifier.issn	1471-0072	en_US
dc.identifier.uri	http://hdl.handle.net/10453/15429
dc.description.abstract	During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs. © 2008 Nature Publishing Group.	en_US
dc.relation.ispartof	Nature Reviews Molecular Cell Biology	en_US
dc.relation.isbasedon	10.1038/nrm2321	en_US
dc.subject.classification	Developmental Biology	en_US
dc.subject.mesh	Germ Cells	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Plants	en_US
dc.subject.mesh	Drosophila Proteins	en_US
dc.subject.mesh	Arabidopsis Proteins	en_US
dc.subject.mesh	Eukaryotic Initiation Factors	en_US
dc.subject.mesh	Eukaryotic Initiation Factor-2	en_US
dc.subject.mesh	RNA, Small Interfering	en_US
dc.subject.mesh	RNA, Untranslated	en_US
dc.subject.mesh	Evolution, Molecular	en_US
dc.subject.mesh	RNA Interference	en_US
dc.subject.mesh	Protein Structure, Tertiary	en_US
dc.subject.mesh	RNA Stability	en_US
dc.subject.mesh	Argonaute Proteins	en_US
dc.title	Argonaute proteins: Key players in RNA silencing	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	9	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
dc.location.activity	ISI:000252231300010	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs. © 2008 Nature Publishing Group.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/15429