Argonaute proteins: Key players in RNA silencing

Publication Type:
Journal Article
Nature Reviews Molecular Cell Biology, 2008, 9 (1), pp. 22 - 32
Issue Date:
Full metadata record
During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs. © 2008 Nature Publishing Group.
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