Case-Fatality Ratio of Blood Culture-Confirmed Typhoid Fever in Dhaka, Bangladesh.

Yu, AT; Amin, N; Rahman, MW; Gurley, ES; Rahman, KM; Luby, SP

Case-Fatality Ratio of Blood Culture-Confirmed Typhoid Fever in Dhaka, Bangladesh.

Yu, AT Amin, N Rahman, MW Gurley, ES Rahman, KM Luby, SP

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Publisher:: OXFORD UNIV PRESS INC
Publication Type:: Journal Article
Citation:: J Infect Dis, 2018, 218, (suppl_4), pp. S222-S226
Issue Date:: 2018-11-10

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Field	Value	Language
dc.contributor.author	Yu, AT
dc.contributor.author	Amin, N
dc.contributor.author	Rahman, MW
dc.contributor.author	Gurley, ES
dc.contributor.author	Rahman, KM
dc.contributor.author	Luby, SP
dc.date.accessioned	2022-03-14T07:02:47Z
dc.date.available	2018-09-10
dc.date.available	2022-03-14T07:02:47Z
dc.date.issued	2018-11-10
dc.identifier.citation	J Infect Dis, 2018, 218, (suppl_4), pp. S222-S226
dc.identifier.issn	0022-1899
dc.identifier.issn	1537-6613
dc.identifier.uri	http://hdl.handle.net/10453/155217
dc.description.abstract	With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs. We enrolled 1425 patients of all ages with blood culture-confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval, .05%-.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.
dc.format	Print
dc.language	eng
dc.publisher	OXFORD UNIV PRESS INC
dc.relation.ispartof	J Infect Dis
dc.relation.isbasedon	10.1093/infdis/jiy543
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.classification	Microbiology
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Bangladesh
dc.subject.mesh	Blood Culture
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Drug Resistance, Multiple, Bacterial
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Risk Factors
dc.subject.mesh	Salmonella typhi
dc.subject.mesh	Typhoid Fever
dc.subject.mesh	Young Adult
dc.subject.mesh	Humans
dc.subject.mesh	Salmonella typhi
dc.subject.mesh	Typhoid Fever
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Risk Factors
dc.subject.mesh	Drug Resistance, Multiple, Bacterial
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Bangladesh
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Young Adult
dc.subject.mesh	Blood Culture
dc.title	Case-Fatality Ratio of Blood Culture-Confirmed Typhoid Fever in Dhaka, Bangladesh.
dc.type	Journal Article
utslib.citation.volume	218
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/DVC (Research)
pubs.organisational-group	/University of Technology Sydney/DVC (Research)/Institute For Sustainable Futures
utslib.copyright.status	open_access	*
dc.date.updated	2022-03-14T07:02:46Z
pubs.issue	suppl_4
pubs.publication-status	Published
pubs.volume	218
utslib.citation.issue	suppl_4

Abstract:

With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs. We enrolled 1425 patients of all ages with blood culture-confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval, .05%-.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.

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http://hdl.handle.net/10453/155217