A Controlled Clinical-Trial On The Cardiovascular Effects Of Single Doses Of Pseudoephedrine In Hypertensive Patients
- Blackwell Science Ltd
- Publication Type:
- Journal Article
- British Journal Of Clinical Pharmacology, 1989, 28 (3), pp. 369 - 372
- Issue Date:
Twenty hypertensive patients received single oral doses of pseudoephedrine 60 mg or placebo in a double-blind, randomised, crossover trial. Systolic, diastolic, mean arterial blood pressure, and heart rate were measured at 5 min intervals for 30 min prior to and 210 min after the administration of pseudoephedrine or placebo. Statistically significant differences between the two treatments were observed with changes in systolic blood pressure (P < 0.03) and heart rate (P < 0.01) but not in diastolic (P > 0.03) and mean arterial blood pressure (P > 0.1). Minor differences in the number of reported side effects between the two treatments were not statistically significant.
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