Mural Cells: Potential Therapeutic Targets to Bridge Cardiovascular Disease and Neurodegeneration

Lin, A; Peiris, NJ; Dhaliwal, H; Hakim, M; Li, W; Ganesh, S; Ramaswamy, Y; Patel, S; Misra, A

Mural Cells: Potential Therapeutic Targets to Bridge Cardiovascular Disease and Neurodegeneration

Lin, A Peiris, NJ Dhaliwal, H Hakim, M Li, W Ganesh, S Ramaswamy, Y Patel, S Misra, A

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Cells, 2021, 10, (3), pp. 1-25
Issue Date:: 2021-03-08

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Field	Value	Language
dc.contributor.author	Lin, A
dc.contributor.author	Peiris, NJ
dc.contributor.author	Dhaliwal, H
dc.contributor.author	Hakim, M
dc.contributor.author	Li, W
dc.contributor.author	Ganesh, S
dc.contributor.author	Ramaswamy, Y
dc.contributor.author	Patel, S
dc.contributor.author	Misra, A
dc.date.accessioned	2022-04-27T22:38:31Z
dc.date.available	2021-03-04
dc.date.available	2022-04-27T22:38:31Z
dc.date.issued	2021-03-08
dc.identifier.citation	Cells, 2021, 10, (3), pp. 1-25
dc.identifier.issn	2073-4409
dc.identifier.issn	2073-4409
dc.identifier.uri	http://hdl.handle.net/10453/156705
dc.description.abstract	Mural cells collectively refer to the smooth muscle cells and pericytes of the vasculature. This heterogenous population of cells play a crucial role in the regulation of blood pressure, distribution, and the structural integrity of the vascular wall. As such, dysfunction of mural cells can lead to the pathogenesis and progression of a number of diseases pertaining to the vascular system. Cardiovascular diseases, particularly atherosclerosis, are perhaps the most well-described mural cell-centric case. For instance, atherosclerotic plaques are most often described as being composed of a proliferative smooth muscle cap accompanied by a necrotic core. More recently, the role of dysfunctional mural cells in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, is being recognized. In this review, we begin with an exploration of the mechanisms underlying atherosclerosis and neurodegenerative diseases, such as mural cell plasticity. Next, we highlight a selection of signaling pathways (PDGF, Notch and inflammatory signaling) that are conserved across both diseases. We propose that conserved mural cell signaling mechanisms can be exploited for the identification or development of dual-pronged therapeutics that impart both cardio- and neuroprotective qualities.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	Cells
dc.relation.isbasedon	10.3390/cells10030593
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Animals
dc.subject.mesh	Atherosclerosis
dc.subject.mesh	Cardiotonic Agents
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Gene Expression Regulation
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Muscle, Smooth, Vascular
dc.subject.mesh	Myocytes, Smooth Muscle
dc.subject.mesh	Neuroprotective Agents
dc.subject.mesh	Parkinson Disease
dc.subject.mesh	Pericytes
dc.subject.mesh	Plaque, Atherosclerotic
dc.subject.mesh	Platelet-Derived Growth Factor
dc.subject.mesh	Receptors, Notch
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Muscle, Smooth, Vascular
dc.subject.mesh	Pericytes
dc.subject.mesh	Myocytes, Smooth Muscle
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Parkinson Disease
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Platelet-Derived Growth Factor
dc.subject.mesh	Neuroprotective Agents
dc.subject.mesh	Cardiotonic Agents
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Gene Expression Regulation
dc.subject.mesh	Atherosclerosis
dc.subject.mesh	Receptors, Notch
dc.subject.mesh	Plaque, Atherosclerotic
dc.title	Mural Cells: Potential Therapeutic Targets to Bridge Cardiovascular Disease and Neurodegeneration
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Provost
utslib.copyright.status	open_access	*
dc.date.updated	2022-04-27T22:38:27Z
pubs.issue	3
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	3

Abstract:

Mural cells collectively refer to the smooth muscle cells and pericytes of the vasculature. This heterogenous population of cells play a crucial role in the regulation of blood pressure, distribution, and the structural integrity of the vascular wall. As such, dysfunction of mural cells can lead to the pathogenesis and progression of a number of diseases pertaining to the vascular system. Cardiovascular diseases, particularly atherosclerosis, are perhaps the most well-described mural cell-centric case. For instance, atherosclerotic plaques are most often described as being composed of a proliferative smooth muscle cap accompanied by a necrotic core. More recently, the role of dysfunctional mural cells in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, is being recognized. In this review, we begin with an exploration of the mechanisms underlying atherosclerosis and neurodegenerative diseases, such as mural cell plasticity. Next, we highlight a selection of signaling pathways (PDGF, Notch and inflammatory signaling) that are conserved across both diseases. We propose that conserved mural cell signaling mechanisms can be exploited for the identification or development of dual-pronged therapeutics that impart both cardio- and neuroprotective qualities.

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http://hdl.handle.net/10453/156705