Advances in designing of polymeric micelles for biomedical application in brain related diseases.

Kaur, J; Gulati, M; Kapoor, B; Jha, NK; Gupta, PK; Gupta, G; Chellappan, DK; Devkota, HP; Prasher, P; Ansari, MS; Aba Alkhayl, FF; Arshad, MF; Morris, A; Choonara, YE; Adams, J; Dua, K; Singh, SK

Advances in designing of polymeric micelles for biomedical application in brain related diseases.

Kaur, J Gulati, M Kapoor, B Jha, NK Gupta, PK Gupta, G Chellappan, DK Devkota, HP Prasher, P Ansari, MS Aba Alkhayl, FF Arshad, MF Morris, A Choonara, YE Adams, J Dua, K

Singh, SK

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Chem Biol Interact, 2022, pp. 109960
Issue Date:: 2022-05-06

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Field	Value	Language
dc.contributor.author	Kaur, J
dc.contributor.author	Gulati, M
dc.contributor.author	Kapoor, B
dc.contributor.author	Jha, NK
dc.contributor.author	Gupta, PK
dc.contributor.author	Gupta, G
dc.contributor.author	Chellappan, DK
dc.contributor.author	Devkota, HP
dc.contributor.author	Prasher, P
dc.contributor.author	Ansari, MS
dc.contributor.author	Aba Alkhayl, FF
dc.contributor.author	Arshad, MF
dc.contributor.author	Morris, A
dc.contributor.author	Choonara, YE
dc.contributor.author	Adams, J
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Singh, SK
dc.date.accessioned	2022-05-12T00:35:25Z
dc.date.available	2022-04-22
dc.date.available	2022-05-12T00:35:25Z
dc.date.issued	2022-05-06
dc.identifier.citation	Chem Biol Interact, 2022, pp. 109960
dc.identifier.issn	0009-2797
dc.identifier.issn	1872-7786
dc.identifier.uri	http://hdl.handle.net/10453/157254
dc.description.abstract	In recent years, unique physicochemical properties of amphiphilic block copolymers have been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins, peptides and genes. Their unique properties such as nano-size, charge-switching ability, stimuli-responsive cargo release, flexible structure, and self-assembly enable them to overcome limitations of conventional dosage forms that include rapid drug release, drug efflux, and poor brain bioavailability, and poor stability. These limitations hinder their therapeutic efficacy in treating brain diseases. Their ease of functionalization and enhanced penetration and retention effect make them suitable nanocarriers for the diagnosis of various brain diseases. In this context, the present manuscript provides an insight into the progress made in the functionalization of micelles such as the incorporation of stimuli-sensitive moieties in copolymers, conjugation of cargo molecules with the core-forming block via responsive smart linkers, and conjugation of active ligands and imaging moieties with the corona forming block for brain targeting and imaging. Further, the review also expounds on the role of polymeric micelles in delivering neurotherapeutic to the brain. Some patents related to polymeric micelles formulated for brain delivery are also enlisted.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Chem Biol Interact
dc.relation.isbasedon	10.1016/j.cbi.2022.109960
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Toxicology
dc.title	Advances in designing of polymeric micelles for biomedical application in brain related diseases.
dc.type	Journal Article
utslib.location.activity	Ireland
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2022-05-12T00:35:19Z
pubs.publication-status	Published online

Abstract:

In recent years, unique physicochemical properties of amphiphilic block copolymers have been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins, peptides and genes. Their unique properties such as nano-size, charge-switching ability, stimuli-responsive cargo release, flexible structure, and self-assembly enable them to overcome limitations of conventional dosage forms that include rapid drug release, drug efflux, and poor brain bioavailability, and poor stability. These limitations hinder their therapeutic efficacy in treating brain diseases. Their ease of functionalization and enhanced penetration and retention effect make them suitable nanocarriers for the diagnosis of various brain diseases. In this context, the present manuscript provides an insight into the progress made in the functionalization of micelles such as the incorporation of stimuli-sensitive moieties in copolymers, conjugation of cargo molecules with the core-forming block via responsive smart linkers, and conjugation of active ligands and imaging moieties with the corona forming block for brain targeting and imaging. Further, the review also expounds on the role of polymeric micelles in delivering neurotherapeutic to the brain. Some patents related to polymeric micelles formulated for brain delivery are also enlisted.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/157254