Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression.

Satija, S; Kaur, H; Tambuwala, MM; Sharma, P; Vyas, M; Khurana, N; Sharma, N; Bakshi, HA; Charbe, NB; Zacconi, FC; Aljabali, AA; Nammi, S; Dureja, H; Singh, TG; Gupta, G; Dhanjal, DS; Dua, K; Chellappan, DK; Mehta, M

Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression.

Kaur, H Tambuwala, MM Sharma, P Vyas, M Khurana, N Sharma, N Bakshi, HA Charbe, NB Zacconi, FC Aljabali, AA Nammi, S Dureja, H Singh, TG Gupta, G Dhanjal, DS Dua, K

Chellappan, DK Mehta, M

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Curr Mol Pharmacol, 2021, 14, (3), pp. 321-332
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Kaur, H
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Sharma, P
dc.contributor.author	Vyas, M
dc.contributor.author	Khurana, N
dc.contributor.author	Sharma, N
dc.contributor.author	Bakshi, HA
dc.contributor.author	Charbe, NB
dc.contributor.author	Zacconi, FC
dc.contributor.author	Aljabali, AA
dc.contributor.author	Nammi, S
dc.contributor.author	Dureja, H
dc.contributor.author	Singh, TG
dc.contributor.author	Gupta, G
dc.contributor.author	Dhanjal, DS
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Chellappan, DK
dc.contributor.author	Mehta, M
dc.date.accessioned	2022-05-30T01:03:49Z
dc.date.available	2020-10-09
dc.date.available	2022-05-30T01:03:49Z
dc.date.issued	2021
dc.identifier.citation	Curr Mol Pharmacol, 2021, 14, (3), pp. 321-332
dc.identifier.issn	1874-4672
dc.identifier.issn	1874-4702
dc.identifier.uri	http://hdl.handle.net/10453/157810
dc.description.abstract	Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation is one of the widely investigated pathways in the hypoxic tumor microenvironment (TME). HIF-1 is known to activate several adaptive reactions in response to oxygen deficiency in tumor cells. HIF-1 has two subunits, HIF-1β (constitutive) and HIF-1α (inducible). The HIF-1α expression is largely regulated via various cytokines (through PI3K-ACT-mTOR signals), which involves the cascading of several growth factors and oncogenic cascades. These events lead to the loss of cellular tumor suppressant activity through changes in the level of oxygen via oxygen-dependent and oxygen-independent pathways. The significant and crucial role of HIF in cancer progression and its underlying mechanisms have gained much attention lately among the translational researchers in the fields of cancer and biological sciences, which have enabled them to correlate these mechanisms with various other disease modalities. In the present review, we have summarized the key findings related to the role of HIF in the progression of tumors.
dc.format	Print
dc.language	eng
dc.publisher	Bentham Science Publishers Ltd.
dc.relation.ispartof	Curr Mol Pharmacol
dc.relation.isbasedon	10.2174/1874467214666210120154929
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.mesh	Cell Hypoxia
dc.subject.mesh	Humans
dc.subject.mesh	Hypoxia
dc.subject.mesh	Hypoxia-Inducible Factor 1, alpha Subunit
dc.subject.mesh	Neoplasms
dc.subject.mesh	Oxygen
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Oxygen
dc.subject.mesh	Cell Hypoxia
dc.subject.mesh	Hypoxia-Inducible Factor 1, alpha Subunit
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Hypoxia
dc.title	Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression.
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	United Arab Emirates
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2022-05-30T01:03:43Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	14
utslib.citation.issue	3

Abstract:

Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation is one of the widely investigated pathways in the hypoxic tumor microenvironment (TME). HIF-1 is known to activate several adaptive reactions in response to oxygen deficiency in tumor cells. HIF-1 has two subunits, HIF-1β (constitutive) and HIF-1α (inducible). The HIF-1α expression is largely regulated via various cytokines (through PI3K-ACT-mTOR signals), which involves the cascading of several growth factors and oncogenic cascades. These events lead to the loss of cellular tumor suppressant activity through changes in the level of oxygen via oxygen-dependent and oxygen-independent pathways. The significant and crucial role of HIF in cancer progression and its underlying mechanisms have gained much attention lately among the translational researchers in the fields of cancer and biological sciences, which have enabled them to correlate these mechanisms with various other disease modalities. In the present review, we have summarized the key findings related to the role of HIF in the progression of tumors.

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http://hdl.handle.net/10453/157810