Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2.

Vadivalagan, C; Shitut, A; Kamalakannan, S; Chen, R-M; Serrano-Aroca, Á; Mishra, V; Aljabali, AAA; Singh, SK; Chellappan, DK; Gupta, G; Dua, K; El-Tanani, M; Tambuwala, MM; Krishnan, A

Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2.

Vadivalagan, C Shitut, A Kamalakannan, S Chen, R-M Serrano-Aroca, Á Mishra, V Aljabali, AAA Singh, SK Chellappan, DK Gupta, G Dua, K

El-Tanani, M Tambuwala, MM Krishnan, A

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Cell Signal, 2022, 95, pp. 110334
Issue Date:: 2022-07

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Field	Value	Language
dc.contributor.author	Vadivalagan, C
dc.contributor.author	Shitut, A
dc.contributor.author	Kamalakannan, S
dc.contributor.author	Chen, R-M
dc.contributor.author	Serrano-Aroca, Á
dc.contributor.author	Mishra, V
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Singh, SK
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	El-Tanani, M
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Krishnan, A
dc.date.accessioned	2022-06-11T12:24:58Z
dc.date.available	2022-04-14
dc.date.available	2022-06-11T12:24:58Z
dc.date.issued	2022-07
dc.identifier.citation	Cell Signal, 2022, 95, pp. 110334
dc.identifier.issn	0898-6568
dc.identifier.issn	1873-3913
dc.identifier.uri	http://hdl.handle.net/10453/158104
dc.description.abstract	Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Cell Signal
dc.relation.isbasedon	10.1016/j.cellsig.2022.110334
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 1116 Medical Physiology
dc.subject.classification	Biochemistry & Molecular Biology
dc.subject.mesh	COVID-19
dc.subject.mesh	Exosomes
dc.subject.mesh	Humans
dc.subject.mesh	MicroRNAs
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Humans
dc.subject.mesh	MicroRNAs
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Exosomes
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.title	Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2.
dc.type	Journal Article
utslib.citation.volume	95
utslib.location.activity	England
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2022-06-11T12:24:52Z
pubs.publication-status	Published
pubs.volume	95

Abstract:

Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/158104