Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters.

Khanuja, HK; Awasthi, R; Mehta, M; Satija, S; Aljabali, AA; Tambuwala, MM; Chellappan, DK; Dua, K; Dureja, H

Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters.

Khanuja, HK Awasthi, R Mehta, M Satija, S Aljabali, AA Tambuwala, MM Chellappan, DK Dua, K

Dureja, H

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Recent patents on nanotechnology, 2021, 15, (4), pp. 351-366
Issue Date:: 2021-01-01

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Field	Value	Language
dc.contributor.author	Khanuja, HK
dc.contributor.author	Awasthi, R
dc.contributor.author	Mehta, M
dc.contributor.author	Satija, S
dc.contributor.author	Aljabali, AA
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Dureja, H
dc.date.accessioned	2022-06-17T02:05:52Z
dc.date.available	2020-11-06
dc.date.available	2022-06-17T02:05:52Z
dc.date.issued	2021-01-01
dc.identifier.citation	Recent patents on nanotechnology, 2021, 15, (4), pp. 351-366
dc.identifier.issn	1872-2105
dc.identifier.issn	2212-4020
dc.identifier.uri	http://hdl.handle.net/10453/158222
dc.description.abstract	<h4>Background</h4>Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.<h4>Methods</h4>Extensive information related to nanosuspensions and its associated patents were collected using PubMed and Google Scholar.<h4>Results</h4>Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are costeffective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.<h4>Conclusion</h4>Nanosuspensions plays a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, occular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers Ltd.
dc.relation.ispartof	Recent patents on nanotechnology
dc.relation.isbasedon	10.2174/1872210514666201224103010
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0910 Manufacturing Engineering, 1007 Nanotechnology
dc.subject.classification	Nanoscience & Nanotechnology
dc.subject.mesh	Administration, Cutaneous
dc.subject.mesh	Drug-Related Side Effects and Adverse Reactions
dc.subject.mesh	Humans
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Particle Size
dc.subject.mesh	Patents as Topic
dc.subject.mesh	Solubility
dc.subject.mesh	Suspensions
dc.subject.mesh	Humans
dc.subject.mesh	Suspensions
dc.subject.mesh	Administration, Cutaneous
dc.subject.mesh	Particle Size
dc.subject.mesh	Solubility
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Patents as Topic
dc.subject.mesh	Drug-Related Side Effects and Adverse Reactions
dc.title	Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	United Arab Emirates
utslib.for	0910 Manufacturing Engineering
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-06-17T02:05:50Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	15
utslib.citation.issue	4

Abstract:

Background

Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.

Methods

Extensive information related to nanosuspensions and its associated patents were collected using PubMed and Google Scholar.

Results

Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are costeffective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.

Conclusion

Nanosuspensions plays a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, occular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/158222