Biomedical applications of polymeric micelles in the treatment of diabetes mellitus: Current success and future approaches.

Kaur, J; Gulati, M; Zacconi, F; Dureja, H; Loebenberg, R; Ansari, MS; AlOmeir, O; Alam, A; Chellappan, DK; Gupta, G; Jha, NK; Pinto, TDJA; Morris, A; Choonara, YE; Adams, J; Dua, K; Singh, SK

Biomedical applications of polymeric micelles in the treatment of diabetes mellitus: Current success and future approaches.

Kaur, J Gulati, M Zacconi, F Dureja, H Loebenberg, R Ansari, MS AlOmeir, O Alam, A Chellappan, DK Gupta, G Jha, NK Pinto, TDJA Morris, A Choonara, YE Adams, J

Dua, K

Singh, SK

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Publisher:: Informa UK Limited
Publication Type:: Journal Article
Citation:: Expert Opin Drug Deliv, 2022
Issue Date:: 2022-06-13

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Field	Value	Language
dc.contributor.author	Kaur, J
dc.contributor.author	Gulati, M
dc.contributor.author	Zacconi, F
dc.contributor.author	Dureja, H
dc.contributor.author	Loebenberg, R
dc.contributor.author	Ansari, MS
dc.contributor.author	AlOmeir, O
dc.contributor.author	Alam, A
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Jha, NK
dc.contributor.author	Pinto, TDJA
dc.contributor.author	Morris, A
dc.contributor.author	Choonara, YE
dc.contributor.author	Adams, J https://orcid.org/0000-0002-9901-5717
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Singh, SK
dc.date.accessioned	2022-06-21T07:47:25Z
dc.date.available	2022-06-21T07:47:25Z
dc.date.issued	2022-06-13
dc.identifier.citation	Expert Opin Drug Deliv, 2022
dc.identifier.issn	1742-5247
dc.identifier.issn	1744-7593
dc.identifier.uri	http://hdl.handle.net/10453/158298
dc.description.abstract	INTRODUCTION: Diabetes mellitus (DM) is the most common metabolic disease and multifactorial, harming patients worldwide. Extensive research has been carried out in the search for novel drug delivery systems offering reliable control of glucose levels for diabetics, aiming at efficient management of DM. AREAS COVERED: Polymeric micelles (PMs) as smart drug delivery nanocarriers are discussed, focusing on oral drug delivery applications for the management of hyperglycaemia. The most recent approaches used for the preparation of smart PMs employ molecular features of amphiphilic block copolymers (ABCs), such as stimulus sensitivity, ligand conjugation, and as a more specific example the ability to inhibit islet amyloidosis. EXPERT OPINION: PMs provide a unique platform for self-regulated or spatiotemporal drug delivery, mimicking the working mode of pancreatic islets to maintain glucose homeostasis for prolonged periods. This unique characteristic is achieved by tailoring the functional chemistry of ABCs considering the physicochemical traits of PMs, including sensing capabilities, hydrophobicity etc. In addition, the application of ABCs for the inhibition of conformational changes in islet amyloid polypeptide garnered attention as one of the root causes of DM. However, research in this field is limited and further studies at the clinical level are required.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Informa UK Limited
dc.relation.ispartof	Expert Opin Drug Deliv
dc.relation.isbasedon	10.1080/17425247.2022.2087629
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.title	Biomedical applications of polymeric micelles in the treatment of diabetes mellitus: Current success and future approaches.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2022-06-21T07:47:21Z
pubs.publication-status	Published online

Abstract:

INTRODUCTION: Diabetes mellitus (DM) is the most common metabolic disease and multifactorial, harming patients worldwide. Extensive research has been carried out in the search for novel drug delivery systems offering reliable control of glucose levels for diabetics, aiming at efficient management of DM. AREAS COVERED: Polymeric micelles (PMs) as smart drug delivery nanocarriers are discussed, focusing on oral drug delivery applications for the management of hyperglycaemia. The most recent approaches used for the preparation of smart PMs employ molecular features of amphiphilic block copolymers (ABCs), such as stimulus sensitivity, ligand conjugation, and as a more specific example the ability to inhibit islet amyloidosis. EXPERT OPINION: PMs provide a unique platform for self-regulated or spatiotemporal drug delivery, mimicking the working mode of pancreatic islets to maintain glucose homeostasis for prolonged periods. This unique characteristic is achieved by tailoring the functional chemistry of ABCs considering the physicochemical traits of PMs, including sensing capabilities, hydrophobicity etc. In addition, the application of ABCs for the inhibition of conformational changes in islet amyloid polypeptide garnered attention as one of the root causes of DM. However, research in this field is limited and further studies at the clinical level are required.

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http://hdl.handle.net/10453/158298