A potential MRI agent and an anticancer drug encapsulated within CPMV virus-like particles.

Aljabali, AAA; Alzoubi, L; Hamzat, Y; Alqudah, A; Obeid, MA; Al Zoubi, MS; Ennab, RM; Alshaer, W; Albatayneh, K; Al-Trad, B; Alqudah, DA; Chellappan, DK; Gupta, G; Tambuwala, MM; Kamal, D; Evans, DJ

A potential MRI agent and an anticancer drug encapsulated within CPMV virus-like particles.

Aljabali, AAA Alzoubi, L Hamzat, Y Alqudah, A Obeid, MA Al Zoubi, MS Ennab, RM Alshaer, W Albatayneh, K Al-Trad, B Alqudah, DA Chellappan, DK Gupta, G Tambuwala, MM Kamal, D Evans, DJ

Permalink

Publisher:: Bentham Science Publishers
Publication Type:: Journal Article
Citation:: Combinatorial Chemistry and High Throughput Screening, 2021, 24, (10), pp. 1557-1571
Issue Date:: 2021-01-01

Closed Access

	Filename	Description	Size
	19196671_8174350260005671.pdf		5.82 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Alzoubi, L
dc.contributor.author	Hamzat, Y
dc.contributor.author	Alqudah, A
dc.contributor.author	Obeid, MA
dc.contributor.author	Al Zoubi, MS
dc.contributor.author	Ennab, RM
dc.contributor.author	Alshaer, W
dc.contributor.author	Albatayneh, K
dc.contributor.author	Al-Trad, B
dc.contributor.author	Alqudah, DA
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Kamal, D
dc.contributor.author	Evans, DJ
dc.date.accessioned	2022-06-22T00:31:35Z
dc.date.available	2020-07-12
dc.date.available	2022-06-22T00:31:35Z
dc.date.issued	2021-01-01
dc.identifier.citation	Combinatorial Chemistry and High Throughput Screening, 2021, 24, (10), pp. 1557-1571
dc.identifier.issn	1386-2073
dc.identifier.issn	1875-5402
dc.identifier.uri	http://hdl.handle.net/10453/158303
dc.description.abstract	Background: Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition. Objectives: The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty Virus-Like Particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications. Methods: The encapsidation of magnetic materials and anticancer drugs was achieved. SuperscriptCPMV denotes molecules attached to the external surface of CPMV and CPMVSubscript denotes molecules within the interior of the capsid. Results: Here, the generation of novel VLPs incorporating iron-platinum nanoparticles TCPMVFePt and cisplatin (Cis) (TCPMVCis) is reported. TCPMVCis exhibited a cytotoxic IC50 of TCPMVCis on both A549 and MDA-MB-231 cell lines of 1.8 μM and 3.9 μM, respectively after 72 hours of incubation. The TCPMVFePt were prepared as potential MRI contrast agents. Conclusion: Cisplatin loaded VLP (TCPMVCis) is shown to enhance cisplatin cytotoxicity in cancer cell lines with its potency increased by 2.3-folds.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers
dc.relation.ispartof	Combinatorial Chemistry and High Throughput Screening
dc.relation.isbasedon	10.2174/1386207323666200914110012
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 0601 Biochemistry and Cell Biology
dc.subject.classification	Organic Chemistry
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Capsid Proteins
dc.subject.mesh	Capsules
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Cell Survival
dc.subject.mesh	Comovirus
dc.subject.mesh	Contrast Media
dc.subject.mesh	Drug Screening Assays, Antitumor
dc.subject.mesh	Humans
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Humans
dc.subject.mesh	Comovirus
dc.subject.mesh	Capsid Proteins
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Capsules
dc.subject.mesh	Contrast Media
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Drug Screening Assays, Antitumor
dc.subject.mesh	Cell Survival
dc.title	A potential MRI agent and an anticancer drug encapsulated within CPMV virus-like particles.
dc.type	Journal Article
utslib.citation.volume	24
utslib.location.activity	United Arab Emirates
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2022-06-22T00:31:31Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	24
utslib.citation.issue	10

Abstract:

Background: Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition. Objectives: The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty Virus-Like Particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications. Methods: The encapsidation of magnetic materials and anticancer drugs was achieved. SuperscriptCPMV denotes molecules attached to the external surface of CPMV and CPMVSubscript denotes molecules within the interior of the capsid. Results: Here, the generation of novel VLPs incorporating iron-platinum nanoparticles TCPMVFePt and cisplatin (Cis) (TCPMVCis) is reported. TCPMVCis exhibited a cytotoxic IC50 of TCPMVCis on both A549 and MDA-MB-231 cell lines of 1.8 μM and 3.9 μM, respectively after 72 hours of incubation. The TCPMVFePt were prepared as potential MRI contrast agents. Conclusion: Cisplatin loaded VLP (TCPMVCis) is shown to enhance cisplatin cytotoxicity in cancer cell lines with its potency increased by 2.3-folds.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/158303