Pharmaceutical aspects of green synthesized silver nanoparticles: A boon to cancer treatment.

Mishra, V; Nayak, P; Singh, M; Tambuwala, MM; Aljabali, AA; Chellappan, DK; Dua, K

Pharmaceutical aspects of green synthesized silver nanoparticles: A boon to cancer treatment.

Mishra, V Nayak, P Singh, M Tambuwala, MM Aljabali, AA Chellappan, DK Dua, K

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Publisher:: Bentham Science Publishers
Publication Type:: Journal Article
Citation:: Anti-Cancer Agents in Medicinal Chemistry, 2021, 21, (12), pp. 1490-1509
Issue Date:: 2021-01-01

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Field	Value	Language
dc.contributor.author	Mishra, V
dc.contributor.author	Nayak, P
dc.contributor.author	Singh, M
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Aljabali, AA
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2022-06-29T03:19:41Z
dc.date.available	2020-08-06
dc.date.available	2022-06-29T03:19:41Z
dc.date.issued	2021-01-01
dc.identifier.citation	Anti-Cancer Agents in Medicinal Chemistry, 2021, 21, (12), pp. 1490-1509
dc.identifier.issn	1568-0118
dc.identifier.issn	1875-5992
dc.identifier.uri	http://hdl.handle.net/10453/158453
dc.description.abstract	Background: Silver nanoparticles (AgNPs) are among the most investigated nanostructures in recent years, which exhibit more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improvement of tissue restoration, drug delivery, diagnosis, being environmentally friendly, and a boon to cancer treatment. Objective: In the current scenario, the development of safe and effective drug delivery systems is the utmost concern of formulation development scientists as well as clinicians. Methods: Google, Web of Science, and PubMed portals have been searched for potentially relevant literature to get the latest developments and updated information related to different aspects of green synthesized AgNPs along with their biomedical applications, especially in the treatment of different types of cancers. Results: The present review highlights the latest published research regarding the different green approaches for the synthesis of AgNPs, their characterization techniques as well as various biomedical applications, particularly in cancer treatment. In this context, environment-friendly AgNPs are proving themselves as better candidates in terms of size, drug loading and release efficiency, targeting efficiency, minimal drug-associated side effects, pharmacokinetic profiling, and biocompatibility issues. Conclusion: With continuous efforts by multidisciplinary team approaches, nanotechnology-based AgNPs will shed new light on diagnostics and therapeutics in various disease treatments. However, the toxicity issues of AgNPs need greater attention as unanticipated toxic effects must be ruled out for their diversified applications.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers
dc.relation.ispartof	Anti-Cancer Agents in Medicinal Chemistry
dc.relation.isbasedon	10.2174/1871520620666200918111024
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 1112 Oncology and Carcinogenesis
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Drug Screening Assays, Antitumor
dc.subject.mesh	Green Chemistry Technology
dc.subject.mesh	Humans
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Neoplasms
dc.subject.mesh	Silver
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Silver
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Drug Screening Assays, Antitumor
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Green Chemistry Technology
dc.title	Pharmaceutical aspects of green synthesized silver nanoparticles: A boon to cancer treatment.
dc.type	Journal Article
utslib.citation.volume	21
utslib.location.activity	Netherlands
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-06-29T03:19:34Z
pubs.issue	12
pubs.publication-status	Published
pubs.volume	21
utslib.citation.issue	12

Abstract:

Background: Silver nanoparticles (AgNPs) are among the most investigated nanostructures in recent years, which exhibit more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improvement of tissue restoration, drug delivery, diagnosis, being environmentally friendly, and a boon to cancer treatment. Objective: In the current scenario, the development of safe and effective drug delivery systems is the utmost concern of formulation development scientists as well as clinicians. Methods: Google, Web of Science, and PubMed portals have been searched for potentially relevant literature to get the latest developments and updated information related to different aspects of green synthesized AgNPs along with their biomedical applications, especially in the treatment of different types of cancers. Results: The present review highlights the latest published research regarding the different green approaches for the synthesis of AgNPs, their characterization techniques as well as various biomedical applications, particularly in cancer treatment. In this context, environment-friendly AgNPs are proving themselves as better candidates in terms of size, drug loading and release efficiency, targeting efficiency, minimal drug-associated side effects, pharmacokinetic profiling, and biocompatibility issues. Conclusion: With continuous efforts by multidisciplinary team approaches, nanotechnology-based AgNPs will shed new light on diagnostics and therapeutics in various disease treatments. However, the toxicity issues of AgNPs need greater attention as unanticipated toxic effects must be ruled out for their diversified applications.

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http://hdl.handle.net/10453/158453