Systematic review of treatments for diabetic peripheral neuropathy.

Çakici, N; Fakkel, TM; van Neck, JW; Verhagen, AP; Coert, JH

Systematic review of treatments for diabetic peripheral neuropathy.

Çakici, N Fakkel, TM van Neck, JW Verhagen, AP Coert, JH

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Diabetic Medicine, 2016, 33, (11), pp. 1466-1476
Issue Date:: 2016-11

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Field	Value	Language
dc.contributor.author	Çakici, N
dc.contributor.author	Fakkel, TM
dc.contributor.author	van Neck, JW
dc.contributor.author	Verhagen, AP
dc.contributor.author	Coert, JH
dc.date.accessioned	2022-07-19T21:43:00Z
dc.date.available	2016-01-25
dc.date.available	2022-07-19T21:43:00Z
dc.date.issued	2016-11
dc.identifier.citation	Diabetic Medicine, 2016, 33, (11), pp. 1466-1476
dc.identifier.issn	0742-3071
dc.identifier.issn	1464-5491
dc.identifier.uri	http://hdl.handle.net/10453/159035
dc.description.abstract	To evaluate treatment options for neuropathic pain and sensory symptoms resulting from diabetic peripheral neuropathy of the feet.The databases PubMed, Embase and Web-of-Science were searched for randomized controlled trials, published in the period from database inception to 2 July 2015, that evaluated treatments for diabetic peripheral neuropathy of the feet with placebo or standard treatment as comparators. Participants in these trials included people with diabetes mellitus and diabetic peripheral neuropathy who were given any treatment for diabetic peripheral neuropathy. Risk of bias was assessed using the Delphi list of criteria. Data from the trials were extracted using standardized data extraction sheets by two authors independently. All analyses were performed using RevMan 5.2. In case of clinical homogeneity, statistical pooling was performed using a random effects model.This review included 27 trials on pharmacological, non-pharmacological and alternative treatments. In the meta-analysis of trials of α-lipoic acid versus placebo, total symptom score was reduced by -2.45 (95% CI -4.52; -0.39) with 600 mg i.v. α-lipoic acid (three trials), and was reduced by -1.95 (95% CI -2.89; -1.01) with 600 mg oral α-lipoic acid (two trials). Significant improvements in diabetic peripheral neuropathy symptoms were found with opioids, botulinum toxin A, mexidol, reflexology and Thai foot massage, but not with micronutrients, neurotrophic peptide ORG 2677 and photon stimulation therapy.In this review, we found that α-lipoic acid, opioids, botulinum toxin A, mexidol, reflexology and Thai foot massage had significant beneficial results.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Diabetic Medicine
dc.relation.isbasedon	10.1111/dme.13083
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1117 Public Health and Health Services, 1701 Psychology
dc.subject.classification	Endocrinology & Metabolism
dc.subject.mesh	Complementary Therapies
dc.subject.mesh	Diabetic Foot
dc.subject.mesh	Diabetic Neuropathies
dc.subject.mesh	Humans
dc.subject.mesh	Neuralgia
dc.subject.mesh	Pain Management
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Humans
dc.subject.mesh	Neuralgia
dc.subject.mesh	Diabetic Neuropathies
dc.subject.mesh	Diabetic Foot
dc.subject.mesh	Complementary Therapies
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Pain Management
dc.title	Systematic review of treatments for diabetic peripheral neuropathy.
dc.type	Journal Article
utslib.citation.volume	33
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Physiotherapy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-07-19T21:42:58Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	33
utslib.citation.issue	11

Abstract:

To evaluate treatment options for neuropathic pain and sensory symptoms resulting from diabetic peripheral neuropathy of the feet.The databases PubMed, Embase and Web-of-Science were searched for randomized controlled trials, published in the period from database inception to 2 July 2015, that evaluated treatments for diabetic peripheral neuropathy of the feet with placebo or standard treatment as comparators. Participants in these trials included people with diabetes mellitus and diabetic peripheral neuropathy who were given any treatment for diabetic peripheral neuropathy. Risk of bias was assessed using the Delphi list of criteria. Data from the trials were extracted using standardized data extraction sheets by two authors independently. All analyses were performed using RevMan 5.2. In case of clinical homogeneity, statistical pooling was performed using a random effects model.This review included 27 trials on pharmacological, non-pharmacological and alternative treatments. In the meta-analysis of trials of α-lipoic acid versus placebo, total symptom score was reduced by -2.45 (95% CI -4.52; -0.39) with 600 mg i.v. α-lipoic acid (three trials), and was reduced by -1.95 (95% CI -2.89; -1.01) with 600 mg oral α-lipoic acid (two trials). Significant improvements in diabetic peripheral neuropathy symptoms were found with opioids, botulinum toxin A, mexidol, reflexology and Thai foot massage, but not with micronutrients, neurotrophic peptide ORG 2677 and photon stimulation therapy.In this review, we found that α-lipoic acid, opioids, botulinum toxin A, mexidol, reflexology and Thai foot massage had significant beneficial results.

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http://hdl.handle.net/10453/159035