A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts’ Blood Serum with Illicit Drug Use and Non-Addict Persons

Hesaruiyeh, FA; Rajabi, S; Motamed-Jahromi, M; Sarhadi, M; Bell, ML; Khaksefidi, R; Sarhadi, S; Mohammadi, L; Dua, K; Mohammadpour, A; Martelletti, P

A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts’ Blood Serum with Illicit Drug Use and Non-Addict Persons

Hesaruiyeh, FA Rajabi, S Motamed-Jahromi, M Sarhadi, M Bell, ML Khaksefidi, R Sarhadi, S Mohammadi, L Dua, K

Mohammadpour, A Martelletti, P

Permalink

Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: International Journal of Environmental Research and Public Health, 19, (15), pp. 9110-9110

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (315.59 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Hesaruiyeh, FA
dc.contributor.author	Rajabi, S
dc.contributor.author	Motamed-Jahromi, M
dc.contributor.author	Sarhadi, M
dc.contributor.author	Bell, ML
dc.contributor.author	Khaksefidi, R
dc.contributor.author	Sarhadi, S
dc.contributor.author	Mohammadi, L
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Mohammadpour, A
dc.contributor.author	Martelletti, P
dc.date.accessioned	2022-07-27T12:50:34Z
dc.date.available	2022-07-27T12:50:34Z
dc.identifier.citation	International Journal of Environmental Research and Public Health, 19, (15), pp. 9110-9110
dc.identifier.issn	1660-4601
dc.identifier.uri	http://hdl.handle.net/10453/159213
dc.description.abstract	<jats:p>While a large body of literature has shown the health problems of illicit drug use, research is needed on how substance abuse impacts DNA damage and contaminants in blood, especially given Pb-contaminated opium. This pilot study aimed to evaluate the levels of lead (Pb), 8-hydroxy di-guanine (8-oxo-Gua), and malondialdehyde (MDA) in the blood serum of opium addicts and non-addict people. The current study is a case–control study with a cross-sectional design. A sample of 50 opium-addicted and non-addict adults were chosen for this study using convenience and random sampling methods. Participants were divided into two groups: addicts and non-addicts. The atomic absorption spectroscopy method was used to measure the quantity of Pb, and the Enzyme-Linked Immunosorbent Assay (ELISA) method was used to measure the amount of 8-oxo-Gua and MDA. The data were analyzed using an independent t-test. The results show that the amount of Pb in the blood serum of addicted women and men was higher than levels in non-addict men and women, for the study participants (p-value = 0.001). Blood levels were not significantly different between addicts and non-addicts for men or women for 8-oxo-Gua (p-value = 0.647 for women and p-value = 0.785 for men) and MDA (p-value = 0.867 for women and p-value = 0.995 for men). In general, addicts’ blood Pb levels were found to be substantially higher than those of normal non-addict persons in this pilot study. As a result, testing for blood Pb levels in addicts may be informative in instances when symptoms are inconclusive.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation.ispartof	International Journal of Environmental Research and Public Health
dc.relation.isbasedon	10.3390/ijerph19159110
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Toxicology
dc.title	A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts’ Blood Serum with Illicit Drug Use and Non-Addict Persons
dc.type	Journal Article
utslib.citation.volume	19
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2022-07-27T12:50:33Z
pubs.issue	15
pubs.publication-status	Published online
pubs.volume	19
utslib.citation.issue	15

Abstract:

While a large body of literature has shown the health problems of illicit drug use, research is needed on how substance abuse impacts DNA damage and contaminants in blood, especially given Pb-contaminated opium. This pilot study aimed to evaluate the levels of lead (Pb), 8-hydroxy di-guanine (8-oxo-Gua), and malondialdehyde (MDA) in the blood serum of opium addicts and non-addict people. The current study is a case–control study with a cross-sectional design. A sample of 50 opium-addicted and non-addict adults were chosen for this study using convenience and random sampling methods. Participants were divided into two groups: addicts and non-addicts. The atomic absorption spectroscopy method was used to measure the quantity of Pb, and the Enzyme-Linked Immunosorbent Assay (ELISA) method was used to measure the amount of 8-oxo-Gua and MDA. The data were analyzed using an independent t-test. The results show that the amount of Pb in the blood serum of addicted women and men was higher than levels in non-addict men and women, for the study participants (p-value = 0.001). Blood levels were not significantly different between addicts and non-addicts for men or women for 8-oxo-Gua (p-value = 0.647 for women and p-value = 0.785 for men) and MDA (p-value = 0.867 for women and p-value = 0.995 for men). In general, addicts’ blood Pb levels were found to be substantially higher than those of normal non-addict persons in this pilot study. As a result, testing for blood Pb levels in addicts may be informative in instances when symptoms are inconclusive.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/159213