A Practical Approach to Fatigue Management in Colorectal Cancer.

Aapro, M; Scotte, F; Bouillet, T; Currow, D; Vigano, A

A Practical Approach to Fatigue Management in Colorectal Cancer.

Aapro, M Scotte, F Bouillet, T Currow, D

Vigano, A

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Clinical Colorectal Cancer, 2017, 16, (4), pp. 275-285
Issue Date:: 2017

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Field	Value	Language
dc.contributor.author	Aapro, M
dc.contributor.author	Scotte, F
dc.contributor.author	Bouillet, T
dc.contributor.author	Currow, D https://orcid.org/0000-0003-1988-1250
dc.contributor.author	Vigano, A
dc.date.accessioned	2022-07-28T06:35:02Z
dc.date.available	2016-04-27
dc.date.available	2022-07-28T06:35:02Z
dc.date.issued	2017
dc.identifier.citation	Clinical Colorectal Cancer, 2017, 16, (4), pp. 275-285
dc.identifier.issn	1533-0028
dc.identifier.issn	1938-0674
dc.identifier.uri	http://hdl.handle.net/10453/159317
dc.description.abstract	Cancer-related fatigue is serious and complex, as well as one of the most common symptoms experienced by patients with colorectal cancer, with the potential to compromise quality of life, activities of daily living, and ultimately survival. There is a lack of consensus about the definition of cancer-related fatigue; however, definitions have been put forward by the European Association for Palliative Care (EAPC) and the National Comprehensive Cancer Network (NCCN). Numerous cancer- and treatment-related factors can contribute to fatigue, including disease progression, comorbidities, medical complications such as anemia, side effects of other medications, and a number of physical and psychologic factors. This underlines the importance of tackling factors that may contribute to fatigue before reducing the dose of treatment. NCCN guidelines and the EAPC have proposed approaches to managing fatigue in cancer patients; however, relatively few therapeutic agents have been demonstrated to reduce fatigue in randomized controlled trials. It is recognized that physical activity produces many beneficial physiologic modifications to markers of physical performance that can help to counteract various causes of fatigue. In appropriately managed and monitored patients with colorectal cancer, emerging evidence indicates that exercise programs may have a favorable influence on cancer-related fatigue, quality of life, and clinical outcomes, and therefore may help patients tolerate chemotherapy. This review assesses fatigue in patients with colorectal cancer and proposes updates to a treatment algorithm that may help clinicians manage this common problem.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Clinical Colorectal Cancer
dc.relation.isbasedon	10.1016/j.clcc.2016.04.010
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1112 Oncology and Carcinogenesis
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.mesh	Activities of Daily Living
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Colorectal Neoplasms
dc.subject.mesh	Disease Progression
dc.subject.mesh	Exercise
dc.subject.mesh	Fatigue
dc.subject.mesh	Humans
dc.subject.mesh	Quality of Life
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Humans
dc.subject.mesh	Colorectal Neoplasms
dc.subject.mesh	Disease Progression
dc.subject.mesh	Fatigue
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Exercise
dc.subject.mesh	Activities of Daily Living
dc.subject.mesh	Quality of Life
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.title	A Practical Approach to Fatigue Management in Colorectal Cancer.
dc.type	Journal Article
utslib.citation.volume	16
utslib.location.activity	United States
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-07-28T06:35:01Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	16
utslib.citation.issue	4

Abstract:

Cancer-related fatigue is serious and complex, as well as one of the most common symptoms experienced by patients with colorectal cancer, with the potential to compromise quality of life, activities of daily living, and ultimately survival. There is a lack of consensus about the definition of cancer-related fatigue; however, definitions have been put forward by the European Association for Palliative Care (EAPC) and the National Comprehensive Cancer Network (NCCN). Numerous cancer- and treatment-related factors can contribute to fatigue, including disease progression, comorbidities, medical complications such as anemia, side effects of other medications, and a number of physical and psychologic factors. This underlines the importance of tackling factors that may contribute to fatigue before reducing the dose of treatment. NCCN guidelines and the EAPC have proposed approaches to managing fatigue in cancer patients; however, relatively few therapeutic agents have been demonstrated to reduce fatigue in randomized controlled trials. It is recognized that physical activity produces many beneficial physiologic modifications to markers of physical performance that can help to counteract various causes of fatigue. In appropriately managed and monitored patients with colorectal cancer, emerging evidence indicates that exercise programs may have a favorable influence on cancer-related fatigue, quality of life, and clinical outcomes, and therefore may help patients tolerate chemotherapy. This review assesses fatigue in patients with colorectal cancer and proposes updates to a treatment algorithm that may help clinicians manage this common problem.

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http://hdl.handle.net/10453/159317