QLIF-26. SLEEP DISTURBANCE AMONG ADULT PATIENTS WITH PRIMARY AND SECONDARY BRAIN TUMORS AND THEIR CAREGIVERS: A CROSS-SECTIONAL STUDY
- Publisher:
- Oxford University Press
- Publication Type:
- Journal Article
- Citation:
- Neuro-Oncology, 2017, 19, (Suppl 6), pp. vi206-vi207
- Issue Date:
- 2017-11
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Abstract Emerging evidence suggests a close link between sleep disturbance and clinical outcomes and the health-related quality of life in cancer patients. Yet, understanding sleep disturbance is neglected areas in both neuro-oncology care and research. This study aimed to determine the prevalence and predictors of sleep disturbance in brain tumor patients and caregivers, and explore any interaction between the patient-caregiver dyad’s sleep. Fifty-six adult patients with primary malignant (86.5%) or metastatic (13.5%) brain tumors and their family caregivers (N=31) completed a series of self-report questionnaires in an ambulatory neuro-oncology clinic setting in Australia. Sleep patterns and disturbance were assessed with the Pittsburgh Sleep Quality Index and the Insomnia Severity Index. Of patients, 59.6% reported having poor sleep quality and 17.1% having clinical insomnia. Female patients had longer sleep latency (r=0.34, p=0.014), and use of anti-emetic was associated with poorer sleep quality (r=0.33, p=0.022). Multiple linear regression analysis revealed that while pain, depression, fatigue, and hemiparesis symptom accounted for 42% of the variability in sleep quality, hemiparesis symptom was the only significant predictor of poor sleep quality (p=0.001). Insomnia scores were predicted by disrupting sleep environment, depression, and fatigue (p<0.05), but no other clinical variables, such as current treatment or corticosteroid use. Of caregivers, the prevalence of poor sleep quality and clinical insomnia were 60.0% and 16.1%, respectively. Clinical anxiety was reported by 25.8% of caregivers. Anxiety and pain were significant predictors of sleep quality and insomnia in caregivers (p<0.05). Sleep patterns and scores of the patient-caregiver dyad were not associated. A substantially high prevalence of sleep disturbance and clinical insomnia was found in patients and family caregivers. Demographic and clinical variables had limited influence, indicating that sleep disturbance is a more complex problem than toxicity in this sample. Understanding underlying mechanisms of co-morbid symptoms and options for managements is still warranted.
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