White matter connectivity in neonates at risk of stuttering: Preliminary data

Packman, A; Onslow, M; Lagopoulos, J; Shan, ZY; Lowe, R; Jones, M; O'Brian, S; Sommer, M

White matter connectivity in neonates at risk of stuttering: Preliminary data

Packman, A

Onslow, M

Lagopoulos, J Shan, ZY Lowe, R

Jones, M O'Brian, S

Sommer, M

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Publisher:: ELSEVIER IRELAND LTD
Publication Type:: Journal Article
Citation:: Neuroscience Letters, 2022, 781, pp. 136655
Issue Date:: 2022-04-01

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Field	Value	Language
dc.contributor.author	Packman, A https://orcid.org/0000-0001-7378-326X
dc.contributor.author	Onslow, M https://orcid.org/0000-0003-2629-2390
dc.contributor.author	Lagopoulos, J
dc.contributor.author	Shan, ZY
dc.contributor.author	Lowe, R https://orcid.org/0000-0003-3826-5306
dc.contributor.author	Jones, M
dc.contributor.author	O'Brian, S https://orcid.org/0000-0002-0882-1909
dc.contributor.author	Sommer, M
dc.date.accessioned	2022-08-02T06:03:51Z
dc.date.available	2022-04-20
dc.date.available	2022-08-02T06:03:51Z
dc.date.issued	2022-04-01
dc.identifier.citation	Neuroscience Letters, 2022, 781, pp. 136655
dc.identifier.issn	0304-3940
dc.identifier.issn	1872-7972
dc.identifier.uri	http://hdl.handle.net/10453/159489
dc.description.abstract	BACKGROUND: Developmental stuttering is thought to be underpinned by structural impairments in the brain. The only way to support the claim that these are causal is to determine if they are present before onset. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) was conducted on 18 neonates, aged 8-18 weeks, 6 of whom were determined to be genetically at risk of stuttering. RESULTS: With tract-based spatial statistics (TBSS) analysis, no statistically significant differences were found between the at-risk group and the control group. However, fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) in the corpus callosum of the at-risk group were lower (uncorrected) than in the control group. Automated Fiber Quantification (AFQ) yielded lower FA in the at-risk group than in the control group in the medial section of the callosum forceps minor. DISCUSSION: The findings, albeit with a small number of participants, support the proposition that reduced integrity of white matter in the corpus callosum has a causal role in developmental stuttering. Longitudinal research to determine if children with this impairment at birth later start to stutter is needed to confirm this. The left arcuate fasciculus is thought to develop as speech develops, which likely explains why there were no abnormal findings in this area in our at-risk neonates so soon after birth. This is the first study to investigate the brains of children before the onset of stuttering, and the findings warrant further research.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER IRELAND LTD
dc.relation	http://purl.org/au-research/grants/arc/DP150101353
dc.relation.ispartof	Neuroscience Letters
dc.relation.isbasedon	10.1016/j.neulet.2022.136655
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
dc.subject.mesh	Anisotropy
dc.subject.mesh	Brain
dc.subject.mesh	Child
dc.subject.mesh	Corpus Callosum
dc.subject.mesh	Diffusion Tensor Imaging
dc.subject.mesh	Humans
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Preliminary Data
dc.subject.mesh	Stuttering
dc.subject.mesh	White Matter
dc.subject.mesh	Brain
dc.subject.mesh	Corpus Callosum
dc.subject.mesh	Humans
dc.subject.mesh	Stuttering
dc.subject.mesh	Anisotropy
dc.subject.mesh	Child
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Diffusion Tensor Imaging
dc.subject.mesh	White Matter
dc.subject.mesh	Preliminary Data
dc.title	White matter connectivity in neonates at risk of stuttering: Preliminary data
dc.type	Journal Article
utslib.citation.volume	781
utslib.location.activity	Ireland
utslib.for	1109 Neurosciences
utslib.for	1701 Psychology
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - ASRC Australian Stuttering Research Centre
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Australian Stuttering Research Centre
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2022-08-02T06:03:49Z
pubs.publication-status	Published
pubs.volume	781

Abstract:

BACKGROUND: Developmental stuttering is thought to be underpinned by structural impairments in the brain. The only way to support the claim that these are causal is to determine if they are present before onset. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) was conducted on 18 neonates, aged 8-18 weeks, 6 of whom were determined to be genetically at risk of stuttering. RESULTS: With tract-based spatial statistics (TBSS) analysis, no statistically significant differences were found between the at-risk group and the control group. However, fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) in the corpus callosum of the at-risk group were lower (uncorrected) than in the control group. Automated Fiber Quantification (AFQ) yielded lower FA in the at-risk group than in the control group in the medial section of the callosum forceps minor. DISCUSSION: The findings, albeit with a small number of participants, support the proposition that reduced integrity of white matter in the corpus callosum has a causal role in developmental stuttering. Longitudinal research to determine if children with this impairment at birth later start to stutter is needed to confirm this. The left arcuate fasciculus is thought to develop as speech develops, which likely explains why there were no abnormal findings in this area in our at-risk neonates so soon after birth. This is the first study to investigate the brains of children before the onset of stuttering, and the findings warrant further research.

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http://hdl.handle.net/10453/159489