Intra-Body Molecular Communication via Blood-Tissue Barrier for Internet of Bio-Nano Things

Al-Zubi, MM; Mohan, AS; Plapper, P; Ling, SH

Intra-Body Molecular Communication via Blood-Tissue Barrier for Internet of Bio-Nano Things

Al-Zubi, MM Mohan, AS Plapper, P Ling, SH

Permalink

Publisher:: Institute of Electrical and Electronics Engineers (IEEE)
Publication Type:: Journal Article
Citation:: IEEE Internet of Things Journal, 2022, pp. 1-1
Issue Date:: 2022-01-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

The embargo period expires on 10 Jun 2024

Adobe PDF

Download Accepted versionAdobe PDF (1.08 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Al-Zubi, MM
dc.contributor.author	Mohan, AS
dc.contributor.author	Plapper, P
dc.contributor.author	Ling, SH
dc.date.accessioned	2022-08-04T01:58:44Z
dc.date.available	2022-08-04T01:58:44Z
dc.date.issued	2022-01-01
dc.identifier.citation	IEEE Internet of Things Journal, 2022, pp. 1-1
dc.identifier.issn	2327-4662
dc.identifier.issn	2327-4662
dc.identifier.uri	http://hdl.handle.net/10453/159605
dc.description.abstract	Molecular communication is an emerging communication paradigm that allows bio-nanomachines to communicate using biochemical molecules as information carriers. It can be used in many promising biomedical applications such as the Internet of Bio-Nano Things (IoBNT) for targeted drug delivery and healthcare applications. In particular, the blood-tissue barrier inside the body forms the main communication pathway for molecular information exchange between the nanomachines as well as between the intra-body nanonetwork and the Bio-Cyber interface in the IoBNT network. However, overcoming this barrier by the molecules is one of the main challenges for molecular communication in the body. Therefore, spatiotemporal modeling of molecular communication across the blood-tissue barrier is of particular interest. In this paper, we develop a mathematical model and stochastic particle-based simulator for molecular communication over high spatiotemporal resolution between mobile bio-nanomachines in the blood capillary and the surrounding tissue. The transmitting bio-nanomachine is modeled as a moving sphere with a continuous emission pattern over a specific duration. In this work, the blood capillary characteristics including the blood-tissue barrier and blood flow are modelled and their effect is examined on the molecular received signal. In addition, we examined the impact of the emission duration, the elimination rate, and the separation distance on the molecular received signal. The numerical results are verified using the developed particle-based simulator. This work can help in the optimum design and development of the IoBNT systems based on molecular communication for biomedical applications such as smart drug delivery and health monitoring systems.
dc.language	en
dc.publisher	Institute of Electrical and Electronics Engineers (IEEE)
dc.relation.ispartof	IEEE Internet of Things Journal
dc.relation.isbasedon	10.1109/JIOT.2022.3182150
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0805 Distributed Computing, 1005 Communications Technologies
dc.title	Intra-Body Molecular Communication via Blood-Tissue Barrier for Internet of Bio-Nano Things
dc.type	Journal Article
utslib.for	0805 Distributed Computing
utslib.for	1005 Communications Technologies
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2024-06-10T00:00:00+1000Z
dc.date.updated	2022-08-04T01:58:43Z
pubs.publication-status	Published

Abstract:

Molecular communication is an emerging communication paradigm that allows bio-nanomachines to communicate using biochemical molecules as information carriers. It can be used in many promising biomedical applications such as the Internet of Bio-Nano Things (IoBNT) for targeted drug delivery and healthcare applications. In particular, the blood-tissue barrier inside the body forms the main communication pathway for molecular information exchange between the nanomachines as well as between the intra-body nanonetwork and the Bio-Cyber interface in the IoBNT network. However, overcoming this barrier by the molecules is one of the main challenges for molecular communication in the body. Therefore, spatiotemporal modeling of molecular communication across the blood-tissue barrier is of particular interest. In this paper, we develop a mathematical model and stochastic particle-based simulator for molecular communication over high spatiotemporal resolution between mobile bio-nanomachines in the blood capillary and the surrounding tissue. The transmitting bio-nanomachine is modeled as a moving sphere with a continuous emission pattern over a specific duration. In this work, the blood capillary characteristics including the blood-tissue barrier and blood flow are modelled and their effect is examined on the molecular received signal. In addition, we examined the impact of the emission duration, the elimination rate, and the separation distance on the molecular received signal. The numerical results are verified using the developed particle-based simulator. This work can help in the optimum design and development of the IoBNT systems based on molecular communication for biomedical applications such as smart drug delivery and health monitoring systems.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/159605