Coupled acoustic-shell model for experimental study of cell stiffness under acoustophoresis

Wijaya, FB; Mohapatra, AR; Sepehrirahnama, S; Lim, KM

Coupled acoustic-shell model for experimental study of cell stiffness under acoustophoresis

Wijaya, FB Mohapatra, AR Sepehrirahnama, S

Lim, KM

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Publisher:: SPRINGER HEIDELBERG
Publication Type:: Journal Article
Citation:: Microfluidics and Nanofluidics, 2016, 20, (5)
Issue Date:: 2016-05-01

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Field	Value	Language
dc.contributor.author	Wijaya, FB
dc.contributor.author	Mohapatra, AR
dc.contributor.author	Sepehrirahnama, S https://orcid.org/0000-0002-3280-3321
dc.contributor.author	Lim, KM
dc.date.accessioned	2022-08-15T22:11:13Z
dc.date.available	2022-08-15T22:11:13Z
dc.date.issued	2016-05-01
dc.identifier.citation	Microfluidics and Nanofluidics, 2016, 20, (5)
dc.identifier.issn	1613-4982
dc.identifier.issn	1613-4990
dc.identifier.uri	http://hdl.handle.net/10453/160266
dc.description.abstract	Under the influence of acoustic radiation force, particles can be trapped and deformed at the pressure node in a microfluidic channel. Based on this principle, the elastic modulus of biological cells can be estimated. In this study, a numerical framework, consisting of a boundary element model for acoustic field and an axisymmetric shell model, is developed to simulate the cell deformation under acoustic radiation force. The boundary element model is used to calculate the radiation traction exerted on the cell surface. The cell membrane deformation due to this traction is simulated by using the axisymmetric shell model. The Young’s moduli of algae and red blood cell membranes are then estimated by comparing the experimental observation with the simulated membrane deformation. It is found that the value of Young’s modulus of the red blood cell membrane is lower than that of algae cell membrane. Furthermore, for both cells, the estimated Young’s moduli are negligible compared to the bulk moduli of the cells reported in the previous studies.
dc.language	English
dc.publisher	SPRINGER HEIDELBERG
dc.relation.ispartof	Microfluidics and Nanofluidics
dc.relation.isbasedon	10.1007/s10404-016-1734-1
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0913 Mechanical Engineering, 0915 Interdisciplinary Engineering, 1007 Nanotechnology
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	Coupled acoustic-shell model for experimental study of cell stiffness under acoustophoresis
dc.type	Journal Article
utslib.citation.volume	20
utslib.for	0913 Mechanical Engineering
utslib.for	0915 Interdisciplinary Engineering
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-15T22:11:12Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	20
utslib.citation.issue	5

Abstract:

Under the influence of acoustic radiation force, particles can be trapped and deformed at the pressure node in a microfluidic channel. Based on this principle, the elastic modulus of biological cells can be estimated. In this study, a numerical framework, consisting of a boundary element model for acoustic field and an axisymmetric shell model, is developed to simulate the cell deformation under acoustic radiation force. The boundary element model is used to calculate the radiation traction exerted on the cell surface. The cell membrane deformation due to this traction is simulated by using the axisymmetric shell model. The Young’s moduli of algae and red blood cell membranes are then estimated by comparing the experimental observation with the simulated membrane deformation. It is found that the value of Young’s modulus of the red blood cell membrane is lower than that of algae cell membrane. Furthermore, for both cells, the estimated Young’s moduli are negligible compared to the bulk moduli of the cells reported in the previous studies.

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http://hdl.handle.net/10453/160266