Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure.

Shirbin, SJ; Lam, SJ; Chan, NJ-A; Ozmen, MM; Fu, Q; O'Brien-Simpson, N; Reynolds, EC; Qiao, GG

Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure.

Shirbin, SJ Lam, SJ Chan, NJ-A Ozmen, MM Fu, Q

O'Brien-Simpson, N Reynolds, EC Qiao, GG

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: ACS Macro Lett, 2016, 5, (5), pp. 552-557
Issue Date:: 2016-05-17

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Field	Value	Language
dc.contributor.author	Shirbin, SJ
dc.contributor.author	Lam, SJ
dc.contributor.author	Chan, NJ-A
dc.contributor.author	Ozmen, MM
dc.contributor.author	Fu, Q https://orcid.org/0000-0002-4012-330X
dc.contributor.author	O'Brien-Simpson, N
dc.contributor.author	Reynolds, EC
dc.contributor.author	Qiao, GG
dc.date.accessioned	2022-08-15T23:07:16Z
dc.date.available	2022-08-15T23:07:16Z
dc.date.issued	2016-05-17
dc.identifier.citation	ACS Macro Lett, 2016, 5, (5), pp. 552-557
dc.identifier.issn	2161-1653
dc.identifier.issn	2161-1653
dc.identifier.uri	http://hdl.handle.net/10453/160275
dc.description.abstract	Synthetic polypeptide-based macroporous cryogels with inherent antimicrobial properties were prepared for potential water purification applications. Gels were chemically cross-linked through the amine residue of a polycationic polylysine-b-polyvaline block copolymer with glutaraldehyde as cross-linker under cryogenic conditions. These cryogels exhibited excellent water swelling and highly compressible mechanical properties owing to their macroporous structure. The antibacterial performance was evaluated based on E. coli viability, with cryogels exhibiting up to 95.6% reduction in viable E. coli after a brief 1 h incubation. In comparison to the hydrogel control, the presence of macropores is shown to be vital to the antimicrobial effect of the gels. The confined environment and increased antimicrobial surface area of the macropores is believed to result in a "trap and kill" mechanism. Mechanical strength and pore integrity of cryogels were also found to be determinants for antibacterial activity. Along with the lack of toxic leaching, these cryogels with inherent antimicrobial properties pose as potential candidates for use in biological and environmentally friendly water purification applications.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	AMER CHEMICAL SOC
dc.relation.ispartof	ACS Macro Lett
dc.relation.isbasedon	10.1021/acsmacrolett.6b00174
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0306 Physical Chemistry (incl. Structural)
dc.title	Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure.
dc.type	Journal Article
utslib.citation.volume	5
utslib.location.activity	United States
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0306 Physical Chemistry (incl. Structural)
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-15T23:07:13Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	5
utslib.citation.issue	5

Abstract:

Synthetic polypeptide-based macroporous cryogels with inherent antimicrobial properties were prepared for potential water purification applications. Gels were chemically cross-linked through the amine residue of a polycationic polylysine-b-polyvaline block copolymer with glutaraldehyde as cross-linker under cryogenic conditions. These cryogels exhibited excellent water swelling and highly compressible mechanical properties owing to their macroporous structure. The antibacterial performance was evaluated based on E. coli viability, with cryogels exhibiting up to 95.6% reduction in viable E. coli after a brief 1 h incubation. In comparison to the hydrogel control, the presence of macropores is shown to be vital to the antimicrobial effect of the gels. The confined environment and increased antimicrobial surface area of the macropores is believed to result in a "trap and kill" mechanism. Mechanical strength and pore integrity of cryogels were also found to be determinants for antibacterial activity. Along with the lack of toxic leaching, these cryogels with inherent antimicrobial properties pose as potential candidates for use in biological and environmentally friendly water purification applications.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/160275