Impact of Opioid Therapy on Sleep and Respiratory Patterns in Adults With Advanced Cancer Receiving Palliative Care.

Good, P; Pinkerton, R; Bowler, S; Craig, J; Hardy, J

Impact of Opioid Therapy on Sleep and Respiratory Patterns in Adults With Advanced Cancer Receiving Palliative Care.

Good, P

Pinkerton, R Bowler, S Craig, J Hardy, J

Permalink

Publisher:: ELSEVIER SCIENCE INC
Publication Type:: Journal Article
Citation:: J Pain Symptom Manage, 2018, 55, (3), pp. 962-967
Issue Date:: 2018-03

Closed Access

	Filename	Description	Size
	PIIS0885392417306917.pdf	Published version	140.87 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Good, P https://orcid.org/0000-0002-8198-0375
dc.contributor.author	Pinkerton, R
dc.contributor.author	Bowler, S
dc.contributor.author	Craig, J
dc.contributor.author	Hardy, J
dc.date.accessioned	2022-09-12T00:52:08Z
dc.date.available	2017-11-22
dc.date.available	2022-09-12T00:52:08Z
dc.date.issued	2018-03
dc.identifier.citation	J Pain Symptom Manage, 2018, 55, (3), pp. 962-967
dc.identifier.issn	0885-3924
dc.identifier.issn	1873-6513
dc.identifier.uri	http://hdl.handle.net/10453/161725
dc.description.abstract	CONTEXT: In advanced cancer, abnormal sleep patterns may contribute to poor quality of life, but the impact of opioid-related sleep disorders has not been explored in detail in these patients. OBJECTIVE: To document sleep and respiratory patterns in patients with cancer, receiving a range of opioids, determine factors that contribute to severity of central or obstructive apnea, and to what extent these contribute to sleep disturbance. METHODS: Adults with advanced cancer admitted to a palliative care service underwent a sleep analysis by an unattended polysomnography. Total sleep time, apnea hypopnea index, central apnea index, obstructive apnea hypopnea index, arousal index, and oxygen desaturation were measured. Baseline assessment included body habitus, Mallampati score, comorbidity indices, concomitant medications, and the Berlin questionnaire. Epworth Sleepiness Scale, Stanford Sleepiness Scale, and Wu cancer fatigue scales were documented. RESULTS: Twenty-eight patients were studied, including 25 receiving opioids. In the latter group, the apnea hypopnea index was mildly abnormal in six patients and severely abnormal in 10 patients. Central apnea index and obstructive apnea hypopnea index were abnormal in nine and 17 patients, respectively. There was no significant correlation between opioid dose and polysomnographic results. CONCLUSION: In patients with advanced cancer receiving opioid analgesia, there was a high prevalence of respiratory disturbance, both central and obstructive, and deranged sleep patterns. Addressing sleep-disordered breathing in cancer patients has the potential to improve daytime drowsiness and quality of life.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE INC
dc.relation.ispartof	J Pain Symptom Manage
dc.relation.isbasedon	10.1016/j.jpainsymman.2017.11.026
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Anesthesiology
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Analgesics, Opioid
dc.subject.mesh	Comorbidity
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Neoplasms
dc.subject.mesh	Palliative Care
dc.subject.mesh	Polysomnography
dc.subject.mesh	Prevalence
dc.subject.mesh	Quality of Life
dc.subject.mesh	Respiration
dc.subject.mesh	Sleep
dc.subject.mesh	Sleep Apnea Syndromes
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Sleep Apnea Syndromes
dc.subject.mesh	Analgesics, Opioid
dc.subject.mesh	Polysomnography
dc.subject.mesh	Palliative Care
dc.subject.mesh	Prevalence
dc.subject.mesh	Sleep
dc.subject.mesh	Comorbidity
dc.subject.mesh	Respiration
dc.subject.mesh	Quality of Life
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.title	Impact of Opioid Therapy on Sleep and Respiratory Patterns in Adults With Advanced Cancer Receiving Palliative Care.
dc.type	Journal Article
utslib.citation.volume	55
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
dc.date.updated	2022-09-12T00:52:07Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	55
utslib.citation.issue	3

Abstract:

CONTEXT: In advanced cancer, abnormal sleep patterns may contribute to poor quality of life, but the impact of opioid-related sleep disorders has not been explored in detail in these patients. OBJECTIVE: To document sleep and respiratory patterns in patients with cancer, receiving a range of opioids, determine factors that contribute to severity of central or obstructive apnea, and to what extent these contribute to sleep disturbance. METHODS: Adults with advanced cancer admitted to a palliative care service underwent a sleep analysis by an unattended polysomnography. Total sleep time, apnea hypopnea index, central apnea index, obstructive apnea hypopnea index, arousal index, and oxygen desaturation were measured. Baseline assessment included body habitus, Mallampati score, comorbidity indices, concomitant medications, and the Berlin questionnaire. Epworth Sleepiness Scale, Stanford Sleepiness Scale, and Wu cancer fatigue scales were documented. RESULTS: Twenty-eight patients were studied, including 25 receiving opioids. In the latter group, the apnea hypopnea index was mildly abnormal in six patients and severely abnormal in 10 patients. Central apnea index and obstructive apnea hypopnea index were abnormal in nine and 17 patients, respectively. There was no significant correlation between opioid dose and polysomnographic results. CONCLUSION: In patients with advanced cancer receiving opioid analgesia, there was a high prevalence of respiratory disturbance, both central and obstructive, and deranged sleep patterns. Addressing sleep-disordered breathing in cancer patients has the potential to improve daytime drowsiness and quality of life.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/161725