Determination of chemo-responses for osteosarcoma using a hybrid evolutionary algorithm
- Publication Type:
- Conference Proceeding
- 2010 IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010, 2010
- Issue Date:
In this paper, a hybrid evolutionary algorithm (HEA) based on the approaches of the evolutionary algorithm and a local search (LS) is proposed to determine the gene signatures for predicting histologic response of chemotherapy on osteosarcoma patients, which is one of the most common malignant bone tumor in children. The HEA consists of a population of individuals but the evolution of individuals is conducted by a LS, rather than the crossover and mutation used in the traditional evolutionary algorithms. The proposed HEA can simultaneously optimize the feature subset and the classifier through a common solution coding mechanism. Experimental results indicate that HEA can obtain more accurate signatures than the other existing approaches in determining chemoresponse for osteosarcoma. © 2010 IEEE.
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