Risk factors for incident kidney disease in older adults: an Australian prospective population-based study.

Kang, A; Sukkar, L; Hockham, C; Jun, M; Young, T; Scaria, A; Foote, C; Neuen, BL; Cass, A; Pollock, C; Comino, E; Lung, T; Pecoits-Filho, R; Rogers, K; Jardine, MJ; EXTEND45 Study Steering Committee†,

Risk factors for incident kidney disease in older adults: an Australian prospective population-based study.

Kang, A Sukkar, L Hockham, C Jun, M Young, T Scaria, A Foote, C Neuen, BL Cass, A Pollock, C Comino, E Lung, T Pecoits-Filho, R Rogers, K

Jardine, MJ EXTEND45 Study Steering Committee†,

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Internal Medicine Journal, 2022, 52, (5), pp. 808-817
Issue Date:: 2022-05

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Field	Value	Language
dc.contributor.author	Kang, A
dc.contributor.author	Sukkar, L
dc.contributor.author	Hockham, C
dc.contributor.author	Jun, M
dc.contributor.author	Young, T
dc.contributor.author	Scaria, A
dc.contributor.author	Foote, C
dc.contributor.author	Neuen, BL
dc.contributor.author	Cass, A
dc.contributor.author	Pollock, C
dc.contributor.author	Comino, E
dc.contributor.author	Lung, T
dc.contributor.author	Pecoits-Filho, R
dc.contributor.author	Rogers, K https://orcid.org/0000-0001-5497-4298
dc.contributor.author	Jardine, MJ
dc.contributor.author	EXTEND45 Study Steering Committee†,
dc.date.accessioned	2022-10-14T02:32:17Z
dc.date.available	2020-09-30
dc.date.available	2022-10-14T02:32:17Z
dc.date.issued	2022-05
dc.identifier.citation	Internal Medicine Journal, 2022, 52, (5), pp. 808-817
dc.identifier.issn	1444-0903
dc.identifier.issn	1445-5994
dc.identifier.uri	http://hdl.handle.net/10453/162588
dc.description.abstract	BACKGROUND AND AIM: To determine risk factors for incident chronic kidney disease (CKD) in a large population-based cohort. METHODS: This prospective opt-in population-based cohort study is based on the 45 and Up Study, where New South Wales residents aged ≥45 years were randomly sampled from the Services Australia database and agreed to complete the 45 and Up Study baseline questionnaire and have their responses linked to their health data in routinely collected databases. The primary outcome was the development of incident CKD, defined as eGFR < 60 mL/min/1.73 m2 . CKD incidence was calculated using Poisson regression. Risk factors for incident CKD were assessed using Cox regression in multivariable models. RESULTS: In 39 574 participants who did not have CKD at enrolment, independent factors associated with developing CKD included: older age, regional residence (HR 1.38 (1.27-1.50) for outer regional vs major city), smoking (1.13 (1.00-1.27) for current smoker vs non-smoker), obesity (1.25 (1.16-1.35) for obese vs normal body mass index), diabetes mellitus (1.41 (1.33-1.50)), hypertension (1.53 (1.44-1.62)), coronary heart disease (1.13 (1.07-1.20)), depression/anxiety (1.16 (1.09-1.24)) and cancer (1.29 (1.20-1.39)). Migrants were less likely to develop CKD compared with people born in Australia (0.88 (0.83-0.94)). Gender, partner status and socioeconomic factors were not independently associated with developing CKD. CONCLUSIONS: This large population-based study found multiple modifiable and non-modifiable factors were independently associated with developing CKD. In the Australian setting, the risk of CKD was higher with regional residence. Differences according to socioeconomic status were predominantly explained by age, comorbidities and harmful health-related behaviours.
dc.format	Print
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Internal Medicine Journal
dc.relation.isbasedon	10.1111/imj.15074
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1117 Public Health and Health Services
dc.subject.classification	General & Internal Medicine
dc.subject.mesh	Aged
dc.subject.mesh	Australia
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Female
dc.subject.mesh	Glomerular Filtration Rate
dc.subject.mesh	Humans
dc.subject.mesh	Incidence
dc.subject.mesh	Male
dc.subject.mesh	Obesity
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Renal Insufficiency, Chronic
dc.subject.mesh	Risk Factors
dc.subject.mesh	Aged
dc.subject.mesh	Australia
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Female
dc.subject.mesh	Glomerular Filtration Rate
dc.subject.mesh	Humans
dc.subject.mesh	Incidence
dc.subject.mesh	Male
dc.subject.mesh	Obesity
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Renal Insufficiency, Chronic
dc.subject.mesh	Risk Factors
dc.subject.mesh	Humans
dc.subject.mesh	Obesity
dc.subject.mesh	Glomerular Filtration Rate
dc.subject.mesh	Incidence
dc.subject.mesh	Risk Factors
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Aged
dc.subject.mesh	Australia
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Renal Insufficiency, Chronic
dc.title	Risk factors for incident kidney disease in older adults: an Australian prospective population-based study.
dc.type	Journal Article
utslib.citation.volume	52
utslib.location.activity	Australia
utslib.for	1102 Cardiorespiratory Medicine and Haematology
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-10-14T02:32:15Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	52
utslib.citation.issue	5

Abstract:

BACKGROUND AND AIM: To determine risk factors for incident chronic kidney disease (CKD) in a large population-based cohort. METHODS: This prospective opt-in population-based cohort study is based on the 45 and Up Study, where New South Wales residents aged ≥45 years were randomly sampled from the Services Australia database and agreed to complete the 45 and Up Study baseline questionnaire and have their responses linked to their health data in routinely collected databases. The primary outcome was the development of incident CKD, defined as eGFR < 60 mL/min/1.73 m2 . CKD incidence was calculated using Poisson regression. Risk factors for incident CKD were assessed using Cox regression in multivariable models. RESULTS: In 39 574 participants who did not have CKD at enrolment, independent factors associated with developing CKD included: older age, regional residence (HR 1.38 (1.27-1.50) for outer regional vs major city), smoking (1.13 (1.00-1.27) for current smoker vs non-smoker), obesity (1.25 (1.16-1.35) for obese vs normal body mass index), diabetes mellitus (1.41 (1.33-1.50)), hypertension (1.53 (1.44-1.62)), coronary heart disease (1.13 (1.07-1.20)), depression/anxiety (1.16 (1.09-1.24)) and cancer (1.29 (1.20-1.39)). Migrants were less likely to develop CKD compared with people born in Australia (0.88 (0.83-0.94)). Gender, partner status and socioeconomic factors were not independently associated with developing CKD. CONCLUSIONS: This large population-based study found multiple modifiable and non-modifiable factors were independently associated with developing CKD. In the Australian setting, the risk of CKD was higher with regional residence. Differences according to socioeconomic status were predominantly explained by age, comorbidities and harmful health-related behaviours.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/162588