HDL maturation and remodelling.

Ong, K-L; Cochran, BJ; Manandhar, B; Thomas, S; Rye, K-A

HDL maturation and remodelling.

Ong, K-L Cochran, BJ Manandhar, B

Thomas, S Rye, K-A

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: BBA: Molecular and Cell Biology of Lipids, 2022, 1867, (4), pp. 1-11
Issue Date:: 2022-04

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Field	Value	Language
dc.contributor.author	Ong, K-L
dc.contributor.author	Cochran, BJ
dc.contributor.author	Manandhar, B https://orcid.org/0000-0003-1276-6954
dc.contributor.author	Thomas, S
dc.contributor.author	Rye, K-A
dc.date.accessioned	2022-11-09T03:45:42Z
dc.date.available	2022-01-20
dc.date.available	2022-11-09T03:45:42Z
dc.date.issued	2022-04
dc.identifier.citation	BBA: Molecular and Cell Biology of Lipids, 2022, 1867, (4), pp. 1-11
dc.identifier.issn	1388-1981
dc.identifier.issn	1879-2618
dc.identifier.uri	http://hdl.handle.net/10453/163364
dc.description.abstract	Cholesterol in the circulation is mostly transported in an esterified form as a component of lipoproteins. The majority of these cholesteryl esters are produced in nascent, discoidal high density lipoproteins (HDLs) by the enzyme, lecithin:cholesterol acyltransferase (LCAT). Discoidal HDLs are discrete populations of particles that consist of a phospholipid bilayer, the hydrophobic acyl chains of which are shielded from the aqueous environment by apolipoproteins that also confer water solubility on the particles. The progressive LCAT-mediated accumulation of cholesteryl esters in discoidal HDLs generates the spherical HDLs that predominate in normal human plasma. Spherical HDLs contain a core of water insoluble, neutral lipids (cholesteryl esters and triglycerides) that is surrounded by a surface monolayer of phospholipids with which apolipoproteins associate. Although spherical HDLs all have the same basic structure, they are extremely diverse in size, composition, and function. This review is concerned with how the biogenesis of discoidal and spherical HDLs is regulated and the mechanistic basis of their size and compositional heterogeneity. Current understanding of the impact of this heterogeneity on the therapeutic potential of HDLs of varying size and composition is also addressed in the context of several disease states.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	BBA: Molecular and Cell Biology of Lipids
dc.relation.isbasedon	10.1016/j.bbalip.2022.159119
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.mesh	Apolipoproteins
dc.subject.mesh	Cholesterol Esters
dc.subject.mesh	Humans
dc.subject.mesh	Lipoproteins, HDL
dc.subject.mesh	Phosphatidylcholine-Sterol O-Acyltransferase
dc.subject.mesh	Phospholipids
dc.subject.mesh	Water
dc.subject.mesh	Apolipoproteins
dc.subject.mesh	Cholesterol Esters
dc.subject.mesh	Humans
dc.subject.mesh	Lipoproteins, HDL
dc.subject.mesh	Phosphatidylcholine-Sterol O-Acyltransferase
dc.subject.mesh	Phospholipids
dc.subject.mesh	Water
dc.subject.mesh	Humans
dc.subject.mesh	Water
dc.subject.mesh	Cholesterol Esters
dc.subject.mesh	Phosphatidylcholine-Sterol O-Acyltransferase
dc.subject.mesh	Lipoproteins, HDL
dc.subject.mesh	Phospholipids
dc.subject.mesh	Apolipoproteins
dc.title	HDL maturation and remodelling.
dc.type	Journal Article
utslib.citation.volume	1867
utslib.location.activity	Netherlands
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-09T03:45:41Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	1867
utslib.citation.issue	4

Abstract:

Cholesterol in the circulation is mostly transported in an esterified form as a component of lipoproteins. The majority of these cholesteryl esters are produced in nascent, discoidal high density lipoproteins (HDLs) by the enzyme, lecithin:cholesterol acyltransferase (LCAT). Discoidal HDLs are discrete populations of particles that consist of a phospholipid bilayer, the hydrophobic acyl chains of which are shielded from the aqueous environment by apolipoproteins that also confer water solubility on the particles. The progressive LCAT-mediated accumulation of cholesteryl esters in discoidal HDLs generates the spherical HDLs that predominate in normal human plasma. Spherical HDLs contain a core of water insoluble, neutral lipids (cholesteryl esters and triglycerides) that is surrounded by a surface monolayer of phospholipids with which apolipoproteins associate. Although spherical HDLs all have the same basic structure, they are extremely diverse in size, composition, and function. This review is concerned with how the biogenesis of discoidal and spherical HDLs is regulated and the mechanistic basis of their size and compositional heterogeneity. Current understanding of the impact of this heterogeneity on the therapeutic potential of HDLs of varying size and composition is also addressed in the context of several disease states.

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http://hdl.handle.net/10453/163364