Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy.

Dewanjee, S; Chakraborty, P; Bhattacharya, H; Singh, SK; Dua, K; Dey, A; Jha, NK

Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy.

Dewanjee, S Chakraborty, P Bhattacharya, H Singh, SK Dua, K

Dey, A Jha, NK

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Drug Discov Today, 2022, pp. 103409
Issue Date:: 2022-10-17

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Field	Value	Language
dc.contributor.author	Dewanjee, S
dc.contributor.author	Chakraborty, P
dc.contributor.author	Bhattacharya, H
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Dey, A
dc.contributor.author	Jha, NK
dc.date.accessioned	2022-11-09T18:04:44Z
dc.date.available	2022-10-12
dc.date.available	2022-11-09T18:04:44Z
dc.date.issued	2022-10-17
dc.identifier.citation	Drug Discov Today, 2022, pp. 103409
dc.identifier.issn	1359-6446
dc.identifier.issn	1878-5832
dc.identifier.uri	http://hdl.handle.net/10453/163374
dc.description.abstract	Flavonoids are an interesting class of biomolecules that exhibit cancer-inhibitory effects through both chemopreventive and chemotherapeutic activities. However, poor pharmacokinetics (PK) and biopharmaceutical attributes affect their therapeutic efficacy. One of the most promising approaches to resolve these issues is to formulate flavonoids in nanosystems. Different flavonoid nanoformulations have shown therapeutic superiority over free flavonoids. Functionalization of nanoparticles (NPs) further improves their therapeutic efficacy by facilitating site-specific delivery and reducing nonspecific toxicities. In this review, we highlight recent developments in the field of flavonoid-based NPs to gain translational insights into the potential applications of flavonoid-based nanocarriers in cancer management.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Drug Discov Today
dc.relation.isbasedon	10.1016/j.drudis.2022.103409
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.title	Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2022-11-09T18:04:41Z
pubs.publication-status	Published online

Abstract:

Flavonoids are an interesting class of biomolecules that exhibit cancer-inhibitory effects through both chemopreventive and chemotherapeutic activities. However, poor pharmacokinetics (PK) and biopharmaceutical attributes affect their therapeutic efficacy. One of the most promising approaches to resolve these issues is to formulate flavonoids in nanosystems. Different flavonoid nanoformulations have shown therapeutic superiority over free flavonoids. Functionalization of nanoparticles (NPs) further improves their therapeutic efficacy by facilitating site-specific delivery and reducing nonspecific toxicities. In this review, we highlight recent developments in the field of flavonoid-based NPs to gain translational insights into the potential applications of flavonoid-based nanocarriers in cancer management.

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http://hdl.handle.net/10453/163374