Joint associations of adiposity and alcohol consumption with liver disease-related morbidity and mortality risk: findings from the UK Biobank.

Inan-Eroglu, E; Huang, B-H; Ahmadi, MN; Johnson, N; El-Omar, EM; Stamatakis, E

Joint associations of adiposity and alcohol consumption with liver disease-related morbidity and mortality risk: findings from the UK Biobank.

Inan-Eroglu, E Huang, B-H Ahmadi, MN Johnson, N El-Omar, EM Stamatakis, E

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Publisher:: Springer Nature [academic journals on nature.com]
Publication Type:: Journal Article
Citation:: European Journal of Clinical Nutrition, 2022, 76, (1), pp. 74-83
Issue Date:: 2022-01

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Field	Value	Language
dc.contributor.author	Inan-Eroglu, E
dc.contributor.author	Huang, B-H
dc.contributor.author	Ahmadi, MN
dc.contributor.author	Johnson, N
dc.contributor.author	El-Omar, EM
dc.contributor.author	Stamatakis, E
dc.date.accessioned	2022-11-16T23:41:25Z
dc.date.available	2021-04-12
dc.date.available	2022-11-16T23:41:25Z
dc.date.issued	2022-01
dc.identifier.citation	European Journal of Clinical Nutrition, 2022, 76, (1), pp. 74-83
dc.identifier.issn	0954-3007
dc.identifier.issn	1476-5640
dc.identifier.uri	http://hdl.handle.net/10453/163524
dc.description.abstract	BACKGROUND: The incidence of both non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (ALD) are expected to grow as a consequence of the ongoing obesity and alcohol consumption trends. OBJECTIVE: We examined the joint associations of adiposity (body mass index (BMI) and waist circumference (WC)) and alcohol consumption on ALD, NAFLD and liver disease incidence and mortality (n = 465,437). METHODS: Alcohol consumption was categorised based on current UK guidelines (14 units/week). Data were analysed using Cox proportional hazard models. A total of 1090 liver disease deaths, 230 ALD deaths and 192 NAFLD deaths occurred over an average follow-up length of 10.5 ± 1.7 years. RESULTS: In multivariate models, we observed greater point estimates for risk of ALD, NAFLD and liver disease incidence and mortality among overweight/obese participants who consumed alcohol at the same level as normal weight participants. We found that overweight/obese participants who reported alcohol consumption above the guidelines had a greater HR for liver disease incidence and mortality (HR 1.52, 95% CI 1.32, 1.75 and HR 2.20, 95% CI 1.41, 3.44, respectively) than normal weight individuals (HR 0.95, 95% CI 0.83, 1.09 and HR 1.24, 95% CI 0.8, 1.93, respectively). The results for the associations of alcohol consumption and WC with ALD, NAFLD and liver disease mortality were similar. Participants with high WC who reported alcohol consumption above the guidelines had a greater HR for liver disease incidence (HR 1.59, 95% CI 1.35, 1.87) than normal WC individuals (HR 0.85, 95% CI 0.72, 1.01). CONCLUSIONS: We found evidence that being overweight/obese amplified the harmful effect of alcohol on the liver incidence and mortality.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Nature [academic journals on nature.com]
dc.relation.ispartof	European Journal of Clinical Nutrition
dc.relation.isbasedon	10.1038/s41430-021-00923-4
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0908 Food Sciences, 1106 Human Movement and Sports Sciences, 1111 Nutrition and Dietetics
dc.subject.classification	Nutrition & Dietetics
dc.subject.mesh	Adiposity
dc.subject.mesh	Alcohol Drinking
dc.subject.mesh	Biological Specimen Banks
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Humans
dc.subject.mesh	Incidence
dc.subject.mesh	Non-alcoholic Fatty Liver Disease
dc.subject.mesh	Obesity
dc.subject.mesh	Risk Factors
dc.subject.mesh	United Kingdom
dc.subject.mesh	Waist Circumference
dc.subject.mesh	Adiposity
dc.subject.mesh	Alcohol Drinking
dc.subject.mesh	Biological Specimen Banks
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Humans
dc.subject.mesh	Incidence
dc.subject.mesh	Non-alcoholic Fatty Liver Disease
dc.subject.mesh	Obesity
dc.subject.mesh	Risk Factors
dc.subject.mesh	United Kingdom
dc.subject.mesh	Waist Circumference
dc.subject.mesh	Humans
dc.subject.mesh	Obesity
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Incidence
dc.subject.mesh	Risk Factors
dc.subject.mesh	Alcohol Drinking
dc.subject.mesh	Biological Specimen Banks
dc.subject.mesh	Adiposity
dc.subject.mesh	Waist Circumference
dc.subject.mesh	Non-alcoholic Fatty Liver Disease
dc.subject.mesh	United Kingdom
dc.title	Joint associations of adiposity and alcohol consumption with liver disease-related morbidity and mortality risk: findings from the UK Biobank.
dc.type	Journal Article
utslib.citation.volume	76
utslib.location.activity	England
utslib.for	0908 Food Sciences
utslib.for	1106 Human Movement and Sports Sciences
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-16T23:41:23Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	76
utslib.citation.issue	1

Abstract:

BACKGROUND: The incidence of both non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (ALD) are expected to grow as a consequence of the ongoing obesity and alcohol consumption trends. OBJECTIVE: We examined the joint associations of adiposity (body mass index (BMI) and waist circumference (WC)) and alcohol consumption on ALD, NAFLD and liver disease incidence and mortality (n = 465,437). METHODS: Alcohol consumption was categorised based on current UK guidelines (14 units/week). Data were analysed using Cox proportional hazard models. A total of 1090 liver disease deaths, 230 ALD deaths and 192 NAFLD deaths occurred over an average follow-up length of 10.5 ± 1.7 years. RESULTS: In multivariate models, we observed greater point estimates for risk of ALD, NAFLD and liver disease incidence and mortality among overweight/obese participants who consumed alcohol at the same level as normal weight participants. We found that overweight/obese participants who reported alcohol consumption above the guidelines had a greater HR for liver disease incidence and mortality (HR 1.52, 95% CI 1.32, 1.75 and HR 2.20, 95% CI 1.41, 3.44, respectively) than normal weight individuals (HR 0.95, 95% CI 0.83, 1.09 and HR 1.24, 95% CI 0.8, 1.93, respectively). The results for the associations of alcohol consumption and WC with ALD, NAFLD and liver disease mortality were similar. Participants with high WC who reported alcohol consumption above the guidelines had a greater HR for liver disease incidence (HR 1.59, 95% CI 1.35, 1.87) than normal WC individuals (HR 0.85, 95% CI 0.72, 1.01). CONCLUSIONS: We found evidence that being overweight/obese amplified the harmful effect of alcohol on the liver incidence and mortality.

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http://hdl.handle.net/10453/163524