Prenatal alcohol exposure and offspring subsequent alcohol use: A systematic review.

Duko, B; Pereira, G; Tait, RJ; Bedaso, A; Newnham, J; Betts, K; Alati, R

Prenatal alcohol exposure and offspring subsequent alcohol use: A systematic review.

Duko, B Pereira, G Tait, RJ Bedaso, A Newnham, J Betts, K Alati, R

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Drug and Alcohol Dependence, 2022, 232, pp. 1-10
Issue Date:: 2022-03-01

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Field	Value	Language
dc.contributor.author	Duko, B
dc.contributor.author	Pereira, G
dc.contributor.author	Tait, RJ
dc.contributor.author	Bedaso, A
dc.contributor.author	Newnham, J
dc.contributor.author	Betts, K
dc.contributor.author	Alati, R
dc.date.accessioned	2022-11-17T04:30:13Z
dc.date.available	2022-01-17
dc.date.available	2022-11-17T04:30:13Z
dc.date.issued	2022-03-01
dc.identifier.citation	Drug and Alcohol Dependence, 2022, 232, pp. 1-10
dc.identifier.issn	0376-8716
dc.identifier.issn	1879-0046
dc.identifier.uri	http://hdl.handle.net/10453/163555
dc.description.abstract	BACKGROUND: Prenatal alcohol exposure has been found to be associated with adverse physical and mental health outcomes in postnatal life, but the evidence is equivocal as to whether such exposure increases the risk of subsequent alcohol use in the offspring. We systematically reviewed the literature on the association between prenatal alcohol exposure and subsequent alcohol use in the offspring. METHODS: Relevant primary studies were identified via systematic search of PubMed/Medline, SCOPUS, EMBASE and Psych-INFO databases. Articles were also retrieved by reviewing reference lists of the identified studies. Literature searches did not have language and date limits but were restricted to human studies. The revised Newcastle-Ottawa Scale was used to evaluate the methodological quality of the studies included in this review. The protocol of this study was prospectively registered in the PROSPERO. RESULTS: Twelve observational studies, published between 1998 and 2020, were included in the final review. Eight studies (66.7%) reported an increased risk of alcohol use or increased level of alcohol drinking, two studies (16.7%) reported an increased risk of alcohol use disorder and one study (8.3%) reported an increased odds of alcohol sipping in offspring exposed to maternal prenatal alcohol use compared to non-exposed. However, one study (8.3%) reported insufficient statistical evidence for an association between prenatal alcohol exposure and offspring subsequent alcohol use. However, it should be noted that the large amount of variability across studies included in this review may limit more conclusive inference. CONCLUSION: The findings of this review suggest a positive link between prenatal alcohol exposure and offspring's subsequent alcohol use. However, further mechanistic studies that allow stronger causal inference are warranted to further elucidate specific causal pathways.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Drug and Alcohol Dependence
dc.relation.isbasedon	10.1016/j.drugalcdep.2022.109324
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Substance Abuse
dc.subject.mesh	Alcohol Drinking
dc.subject.mesh	Alcoholism
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Pregnancy
dc.subject.mesh	Prenatal Exposure Delayed Effects
dc.subject.mesh	Alcohol Drinking
dc.subject.mesh	Alcoholism
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Pregnancy
dc.subject.mesh	Prenatal Exposure Delayed Effects
dc.subject.mesh	Humans
dc.subject.mesh	Prenatal Exposure Delayed Effects
dc.subject.mesh	Alcoholism
dc.subject.mesh	Alcohol Drinking
dc.subject.mesh	Pregnancy
dc.subject.mesh	Female
dc.title	Prenatal alcohol exposure and offspring subsequent alcohol use: A systematic review.
dc.type	Journal Article
utslib.citation.volume	232
utslib.location.activity	Ireland
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-17T04:30:12Z
pubs.publication-status	Published
pubs.volume	232

Abstract:

BACKGROUND: Prenatal alcohol exposure has been found to be associated with adverse physical and mental health outcomes in postnatal life, but the evidence is equivocal as to whether such exposure increases the risk of subsequent alcohol use in the offspring. We systematically reviewed the literature on the association between prenatal alcohol exposure and subsequent alcohol use in the offspring. METHODS: Relevant primary studies were identified via systematic search of PubMed/Medline, SCOPUS, EMBASE and Psych-INFO databases. Articles were also retrieved by reviewing reference lists of the identified studies. Literature searches did not have language and date limits but were restricted to human studies. The revised Newcastle-Ottawa Scale was used to evaluate the methodological quality of the studies included in this review. The protocol of this study was prospectively registered in the PROSPERO. RESULTS: Twelve observational studies, published between 1998 and 2020, were included in the final review. Eight studies (66.7%) reported an increased risk of alcohol use or increased level of alcohol drinking, two studies (16.7%) reported an increased risk of alcohol use disorder and one study (8.3%) reported an increased odds of alcohol sipping in offspring exposed to maternal prenatal alcohol use compared to non-exposed. However, one study (8.3%) reported insufficient statistical evidence for an association between prenatal alcohol exposure and offspring subsequent alcohol use. However, it should be noted that the large amount of variability across studies included in this review may limit more conclusive inference. CONCLUSION: The findings of this review suggest a positive link between prenatal alcohol exposure and offspring's subsequent alcohol use. However, further mechanistic studies that allow stronger causal inference are warranted to further elucidate specific causal pathways.

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http://hdl.handle.net/10453/163555