Perinatal outcomes of women with gestational breast cancer in Australia and New Zealand: A prospective population-based study.

Sullivan, E; Safi, N; Li, Z; Remond, M; Chen, TYT; Javid, N; Dickinson, JE; Ives, A; Hammarberg, K; Anazodo, A; Boyle, F; Fisher, J; Halliday, L; Duncombe, G; McLintock, C; Wang, AY; Saunders, C

Perinatal outcomes of women with gestational breast cancer in Australia and New Zealand: A prospective population-based study.

Li, Z Remond, M Chen, TYT Javid, N Dickinson, JE Ives, A Hammarberg, K Anazodo, A Boyle, F Fisher, J Halliday, L Duncombe, G McLintock, C Wang, AY Saunders, C

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Birth, 2022, 49, (4), pp. 763-773
Issue Date:: 2022-12

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Field	Value	Language
dc.contributor.author	Sullivan, E https://orcid.org/0000-0002-8718-2753
dc.contributor.author	Safi, N https://orcid.org/0000-0001-8473-0980
dc.contributor.author	Li, Z
dc.contributor.author	Remond, M
dc.contributor.author	Chen, TYT
dc.contributor.author	Javid, N
dc.contributor.author	Dickinson, JE
dc.contributor.author	Ives, A
dc.contributor.author	Hammarberg, K
dc.contributor.author	Anazodo, A
dc.contributor.author	Boyle, F
dc.contributor.author	Fisher, J
dc.contributor.author	Halliday, L
dc.contributor.author	Duncombe, G
dc.contributor.author	McLintock, C
dc.contributor.author	Wang, AY
dc.contributor.author	Saunders, C
dc.date.accessioned	2022-11-30T00:43:48Z
dc.date.available	2022-04-07
dc.date.available	2022-11-30T00:43:48Z
dc.date.issued	2022-12
dc.identifier.citation	Birth, 2022, 49, (4), pp. 763-773
dc.identifier.issn	0730-7659
dc.identifier.issn	1523-536X
dc.identifier.uri	http://hdl.handle.net/10453/163853
dc.description.abstract	OBJECTIVE: To determine the epidemiology, clinical management, and outcomes of women with gestational breast cancer (GBC). METHODS: A population-based prospective cohort study was conducted in Australia and New Zealand between 2013 and 2014 using the Australasian Maternity Outcomes Surveillance System (AMOSS). Women who gave birth with a primary diagnosis of breast cancer during pregnancy were included. Data were collected on demographic and pregnancy factors, GBC diagnosis, obstetric and cancer management, and perinatal outcomes. The main outcome measures were preterm birth, maternal complications, breastfeeding, and death. RESULTS: Forty women with GBC (incidence 7.5/100 000 women giving birth) gave birth to 40 live-born babies. Thirty-three (82.5%) women had breast symptoms at diagnosis. Of 27 women diagnosed before 30 weeks' gestation, 85% had breast surgery and 67% had systemic therapy during pregnancy. In contrast, all 13 women diagnosed from 30 weeks had their cancer management delayed until postdelivery. There were 17 preterm deliveries; 15 were planned. Postpartum complications included the following: hemorrhage (n = 4), laparotomy (n = 1), and thrombocytopenia (n = 1). There was one late maternal death. Eighteen (45.0%) women initiated breastfeeding, including 12 of 23 women who had antenatal breast surgery. There were no perinatal deaths or congenital malformations, but 42.5% of babies were preterm, and 32.5% were admitted for higher-level neonatal care. CONCLUSIONS: Gestational breast cancer diagnosed before 30 weeks' gestation was associated with surgical and systemic cancer care during pregnancy and planned preterm birth. In contrast, cancer treatment was deferred to postdelivery for women diagnosed from 30 weeks, reflecting the complexity of managing expectant mothers with GBC in multidisciplinary care settings.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation	National Breast Cancer FoundationNC-12-38
dc.relation.ispartof	Birth
dc.relation.isbasedon	10.1111/birt.12642
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Obstetrics & Reproductive Medicine
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Pregnancy
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Cesarean Section
dc.subject.mesh	New Zealand
dc.subject.mesh	Premature Birth
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Pregnancy Outcome
dc.subject.mesh	Pregnancy Complications, Neoplastic
dc.subject.mesh	Australia
dc.subject.mesh	Breast Feeding
dc.subject.mesh	Incidence
dc.subject.mesh	Time-to-Treatment
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Pregnancy Complications, Neoplastic
dc.subject.mesh	Premature Birth
dc.subject.mesh	Pregnancy Outcome
dc.subject.mesh	Cesarean Section
dc.subject.mesh	Incidence
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Breast Feeding
dc.subject.mesh	Pregnancy
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Australia
dc.subject.mesh	New Zealand
dc.subject.mesh	Female
dc.subject.mesh	Time-to-Treatment
dc.title	Perinatal outcomes of women with gestational breast cancer in Australia and New Zealand: A prospective population-based study.
dc.type	Journal Article
utslib.citation.volume	49
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	open_access	*
dc.date.updated	2022-11-30T00:43:46Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	49
utslib.citation.issue	4

Abstract:

OBJECTIVE: To determine the epidemiology, clinical management, and outcomes of women with gestational breast cancer (GBC). METHODS: A population-based prospective cohort study was conducted in Australia and New Zealand between 2013 and 2014 using the Australasian Maternity Outcomes Surveillance System (AMOSS). Women who gave birth with a primary diagnosis of breast cancer during pregnancy were included. Data were collected on demographic and pregnancy factors, GBC diagnosis, obstetric and cancer management, and perinatal outcomes. The main outcome measures were preterm birth, maternal complications, breastfeeding, and death. RESULTS: Forty women with GBC (incidence 7.5/100 000 women giving birth) gave birth to 40 live-born babies. Thirty-three (82.5%) women had breast symptoms at diagnosis. Of 27 women diagnosed before 30 weeks' gestation, 85% had breast surgery and 67% had systemic therapy during pregnancy. In contrast, all 13 women diagnosed from 30 weeks had their cancer management delayed until postdelivery. There were 17 preterm deliveries; 15 were planned. Postpartum complications included the following: hemorrhage (n = 4), laparotomy (n = 1), and thrombocytopenia (n = 1). There was one late maternal death. Eighteen (45.0%) women initiated breastfeeding, including 12 of 23 women who had antenatal breast surgery. There were no perinatal deaths or congenital malformations, but 42.5% of babies were preterm, and 32.5% were admitted for higher-level neonatal care. CONCLUSIONS: Gestational breast cancer diagnosed before 30 weeks' gestation was associated with surgical and systemic cancer care during pregnancy and planned preterm birth. In contrast, cancer treatment was deferred to postdelivery for women diagnosed from 30 weeks, reflecting the complexity of managing expectant mothers with GBC in multidisciplinary care settings.

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http://hdl.handle.net/10453/163853