The Australian dingo is an early offshoot of modern breed dogs.

Field, MA; Yadav, S; Dudchenko, O; Esvaran, M; Rosen, BD; Skvortsova, K; Edwards, RJ; Keilwagen, J; Cochran, BJ; Manandhar, B; Bustamante, S; Rasmussen, JA; Melvin, RG; Chernoff, B; Omer, A; Colaric, Z; Chan, EKF; Minoche, AE; Smith, TPL; Gilbert, MTP; Bogdanovic, O; Zammit, RA; Thomas, T; Aiden, EL; Ballard, JWO

The Australian dingo is an early offshoot of modern breed dogs.

Field, MA Yadav, S Dudchenko, O Esvaran, M Rosen, BD Skvortsova, K Edwards, RJ Keilwagen, J Cochran, BJ Manandhar, B

Bustamante, S Rasmussen, JA Melvin, RG Chernoff, B Omer, A Colaric, Z Chan, EKF Minoche, AE Smith, TPL Gilbert, MTP Bogdanovic, O Zammit, RA Thomas, T Aiden, EL Ballard, JWO

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Publisher:: American Association for the Advancement of Science
Publication Type:: Journal Article
Citation:: Science Advances, 2022, 8, (16), pp. 1-14
Issue Date:: 2022-04-22

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Field	Value	Language
dc.contributor.author	Field, MA
dc.contributor.author	Yadav, S
dc.contributor.author	Dudchenko, O
dc.contributor.author	Esvaran, M
dc.contributor.author	Rosen, BD
dc.contributor.author	Skvortsova, K
dc.contributor.author	Edwards, RJ
dc.contributor.author	Keilwagen, J
dc.contributor.author	Cochran, BJ
dc.contributor.author	Manandhar, B https://orcid.org/0000-0003-1276-6954
dc.contributor.author	Bustamante, S
dc.contributor.author	Rasmussen, JA
dc.contributor.author	Melvin, RG
dc.contributor.author	Chernoff, B
dc.contributor.author	Omer, A
dc.contributor.author	Colaric, Z
dc.contributor.author	Chan, EKF
dc.contributor.author	Minoche, AE
dc.contributor.author	Smith, TPL
dc.contributor.author	Gilbert, MTP
dc.contributor.author	Bogdanovic, O
dc.contributor.author	Zammit, RA
dc.contributor.author	Thomas, T
dc.contributor.author	Aiden, EL
dc.contributor.author	Ballard, JWO
dc.date.accessioned	2022-11-30T04:28:14Z
dc.date.available	2022-11-30T04:28:14Z
dc.date.issued	2022-04-22
dc.identifier.citation	Science Advances, 2022, 8, (16), pp. 1-14
dc.identifier.issn	2375-2548
dc.identifier.issn	2375-2548
dc.identifier.uri	http://hdl.handle.net/10453/163920
dc.description.abstract	Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Association for the Advancement of Science
dc.relation.ispartof	Science Advances
dc.relation.isbasedon	10.1126/sciadv.abm5944
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Animals
dc.subject.mesh	Australia
dc.subject.mesh	Breeding
dc.subject.mesh	Canidae
dc.subject.mesh	Dogs
dc.subject.mesh	Phylogeny
dc.subject.mesh	Wolves
dc.subject.mesh	Animals
dc.subject.mesh	Australia
dc.subject.mesh	Breeding
dc.subject.mesh	Canidae
dc.subject.mesh	Dogs
dc.subject.mesh	Phylogeny
dc.subject.mesh	Wolves
dc.subject.mesh	Animals
dc.subject.mesh	Canidae
dc.subject.mesh	Dogs
dc.subject.mesh	Wolves
dc.subject.mesh	Breeding
dc.subject.mesh	Phylogeny
dc.subject.mesh	Australia
dc.title	The Australian dingo is an early offshoot of modern breed dogs.
dc.type	Journal Article
utslib.citation.volume	8
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-30T04:28:10Z
pubs.issue	16
pubs.publication-status	Published
pubs.volume	8
utslib.citation.issue	16

Abstract:

Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.

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http://hdl.handle.net/10453/163920