Field |
Value |
Language |
dc.contributor.author |
Prasher, P |
|
dc.contributor.author |
Sharma, M |
|
dc.contributor.author |
Singh, SK |
|
dc.contributor.author |
Gulati, M |
|
dc.contributor.author |
Chellappan, DK |
|
dc.contributor.author |
Zacconi, F |
|
dc.contributor.author |
De Rubis, G |
|
dc.contributor.author |
Gupta, G |
|
dc.contributor.author |
Sharifi-Rad, J |
|
dc.contributor.author |
Cho, WC |
|
dc.contributor.author |
Dua, K
https://orcid.org/0000-0002-7507-1159
|
|
dc.date.accessioned |
2022-12-09T02:59:09Z |
|
dc.date.available |
2022-12-09T02:59:09Z |
|
dc.identifier.citation |
Cancer Cell International, 22, (1) |
|
dc.identifier.issn |
1475-2867 |
|
dc.identifier.uri |
http://hdl.handle.net/10453/164267
|
|
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, and cancer due to its action as pro-oxidants and antioxidants. The anticancer profile of luteolin is of interest due to the toxic effect of contemporary chemotherapy paradigm, leading to the pressing need for the development and identification of physiologically benevolent anticancer agents and molecules. Luteolin exerts anticancer activity by downregulation of key regulatory pathways associated with oncogenesis, in addition to the induction of oxidative stress, cell cycle arrest, upregulation of apoptotic genes, and inhibition of cell proliferation and angiogenesis in cancer cells. In this review, we discuss about the anticancer profile of luteolin.</jats:p> |
|
dc.language |
en |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartof |
Cancer Cell International |
|
dc.relation.isbasedon |
10.1186/s12935-022-02808-3 |
|
dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject |
0601 Biochemistry and Cell Biology, 1112 Oncology and Carcinogenesis |
|
dc.subject.classification |
Oncology & Carcinogenesis |
|
dc.title |
Luteolin: a flavonoid with a multifaceted anticancer potential |
|
dc.type |
Journal Article |
|
utslib.citation.volume |
22 |
|
utslib.for |
0601 Biochemistry and Cell Biology |
|
utslib.for |
1112 Oncology and Carcinogenesis |
|
pubs.organisational-group |
/University of Technology Sydney |
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health |
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health/Graduate School of Health |
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy |
|
utslib.copyright.status |
open_access |
* |
dc.date.updated |
2022-12-09T02:59:07Z |
|
pubs.issue |
1 |
|
pubs.publication-status |
Published online |
|
pubs.volume |
22 |
|
utslib.citation.issue |
1 |
|