Luteolin: a flavonoid with a multifaceted anticancer potential

Prasher, P; Sharma, M; Singh, SK; Gulati, M; Chellappan, DK; Zacconi, F; De Rubis, G; Gupta, G; Sharifi-Rad, J; Cho, WC; Dua, K

Luteolin: a flavonoid with a multifaceted anticancer potential

Prasher, P Sharma, M Singh, SK Gulati, M Chellappan, DK Zacconi, F De Rubis, G Gupta, G Sharifi-Rad, J Cho, WC Dua, K

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Cancer Cell International, 22, (1)

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Field	Value	Language
dc.contributor.author	Prasher, P
dc.contributor.author	Sharma, M
dc.contributor.author	Singh, SK
dc.contributor.author	Gulati, M
dc.contributor.author	Chellappan, DK
dc.contributor.author	Zacconi, F
dc.contributor.author	De Rubis, G
dc.contributor.author	Gupta, G
dc.contributor.author	Sharifi-Rad, J
dc.contributor.author	Cho, WC
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2022-12-09T02:59:09Z
dc.date.available	2022-12-09T02:59:09Z
dc.identifier.citation	Cancer Cell International, 22, (1)
dc.identifier.issn	1475-2867
dc.identifier.uri	http://hdl.handle.net/10453/164267
dc.description.abstract	<jats:title>Abstract</jats:title><jats:p>Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, and cancer due to its action as pro-oxidants and antioxidants. The anticancer profile of luteolin is of interest due to the toxic effect of contemporary chemotherapy paradigm, leading to the pressing need for the development and identification of physiologically benevolent anticancer agents and molecules. Luteolin exerts anticancer activity by downregulation of key regulatory pathways associated with oncogenesis, in addition to the induction of oxidative stress, cell cycle arrest, upregulation of apoptotic genes, and inhibition of cell proliferation and angiogenesis in cancer cells. In this review, we discuss about the anticancer profile of luteolin.</jats:p>
dc.language	en
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Cancer Cell International
dc.relation.isbasedon	10.1186/s12935-022-02808-3
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 1112 Oncology and Carcinogenesis
dc.subject.classification	Oncology & Carcinogenesis
dc.title	Luteolin: a flavonoid with a multifaceted anticancer potential
dc.type	Journal Article
utslib.citation.volume	22
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2022-12-09T02:59:07Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	22
utslib.citation.issue	1

Abstract:

AbstractTherapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, and cancer due to its action as pro-oxidants and antioxidants. The anticancer profile of luteolin is of interest due to the toxic effect of contemporary chemotherapy paradigm, leading to the pressing need for the development and identification of physiologically benevolent anticancer agents and molecules. Luteolin exerts anticancer activity by downregulation of key regulatory pathways associated with oncogenesis, in addition to the induction of oxidative stress, cell cycle arrest, upregulation of apoptotic genes, and inhibition of cell proliferation and angiogenesis in cancer cells. In this review, we discuss about the anticancer profile of luteolin.

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http://hdl.handle.net/10453/164267