Self-Emulsifying Drug Delivery Systems: A Strategy to Improve the Bioavailability of Hydrophobic Drugs

Banerjee, A; Kumar, R; Gulati, M; Singh, SK; Dua, K; Singh, G; Sharma, PK; Sharma, A

Self-Emulsifying Drug Delivery Systems: A Strategy to Improve the Bioavailability of Hydrophobic Drugs

Banerjee, A Kumar, R Gulati, M Singh, SK Dua, K

Singh, G Sharma, PK Sharma, A

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Publisher:: Apple Academic Press
Publication Type:: Chapter
Citation:: The Era of Nanotechnology Emergence and Essentials, 2022, 1, 1, pp. 22-34
Issue Date:: 2022-07-01

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Field	Value	Language
dc.contributor.author	Banerjee, A
dc.contributor.author	Kumar, R
dc.contributor.author	Gulati, M
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Singh, G
dc.contributor.author	Sharma, PK
dc.contributor.author	Sharma, A
dc.date.accessioned	2023-01-10T08:10:18Z
dc.date.available	2023-01-10T08:10:18Z
dc.date.issued	2022-07-01
dc.identifier.citation	The Era of Nanotechnology Emergence and Essentials, 2022, 1, 1, pp. 22-34
dc.identifier.isbn	9781003160588
dc.identifier.uri	http://hdl.handle.net/10453/164808
dc.description.abstract	Designing efficacious formulations for oral route of drug delivery has been challenging but still warranted because of its high patient compliance. However, drugs in pipeline or any new chemical entities being discovered have always faced key challenges of optimum solubility and permeability without which a product cannot show the claimed activity or even enter the trials. Though there are several intriguing choices of drug development available, lipid-based formulations are gaining popularity owing to their ease of manufacturing and efficacious results. Further, narrowing the base of lipid-formulations which have gained acceptance are micro- and nanoemulsions, whose bars have been raised higher with the introduction of “self-emulsifying drug delivery system” (SEDDS), which has swept off the bits-and-flaws of conventional emulsion. Therefore, this chapter is an attempt to cover all the aspects of SEDDS formulation including “self-micro-emulsifying drug delivery system (SMEDDS)” and “self-nano-emulsifying drug delivery system (SNEDDS)”; a deep dive in its formulation criteria, selection of suitable candidate and components, self-emulsification process, probable fate of the formulation in vivo, transformation techniques, evaluation parameters, 130new approaches in pipeline, dosage forms that can be prepared, challenging aspects lingering around, extensive researches done since last decade to present and patents being granted so far.
dc.format.extent	11
dc.language	en
dc.publisher	Apple Academic Press
dc.relation.ispartof	The Era of Nanotechnology Emergence and Essentials
dc.relation.isbasedon	10.1201/9781003160588-6
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.title	Self-Emulsifying Drug Delivery Systems: A Strategy to Improve the Bioavailability of Hydrophobic Drugs
dc.type	Chapter
utslib.citation.volume	1
utslib.citation.edition	1
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	recently_added	*
pubs.consider-herdc	false
dc.date.updated	2023-01-10T08:10:16Z
pubs.edition	1
pubs.place-of-publication	USA
pubs.publication-status	Published
pubs.volume	1
dc.location	USA

Abstract:

Designing efficacious formulations for oral route of drug delivery has been challenging but still warranted because of its high patient compliance. However, drugs in pipeline or any new chemical entities being discovered have always faced key challenges of optimum solubility and permeability without which a product cannot show the claimed activity or even enter the trials. Though there are several intriguing choices of drug development available, lipid-based formulations are gaining popularity owing to their ease of manufacturing and efficacious results. Further, narrowing the base of lipid-formulations which have gained acceptance are micro- and nanoemulsions, whose bars have been raised higher with the introduction of “self-emulsifying drug delivery system” (SEDDS), which has swept off the bits-and-flaws of conventional emulsion. Therefore, this chapter is an attempt to cover all the aspects of SEDDS formulation including “self-micro-emulsifying drug delivery system (SMEDDS)” and “self-nano-emulsifying drug delivery system (SNEDDS)”; a deep dive in its formulation criteria, selection of suitable candidate and components, self-emulsification process, probable fate of the formulation in vivo, transformation techniques, evaluation parameters, 130new approaches in pipeline, dosage forms that can be prepared, challenging aspects lingering around, extensive researches done since last decade to present and patents being granted so far.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/164808